Figure 2
From: Information-theoretic gene-gene and gene-environment interaction analysis of quantitative traits
Figure 2A shows the interaction model for Simulated Data Set 1. The SNP variables, SNP 1 and SNP 2 sequentially interact (the comma in 2, 3 indicates the Boolean OR operation) to determine the QT level. Figure 2B and 2C are the corresponding KWII and PAI spectra for an effect size of 0.5. Figure 2D shows the dependence of KWII on effect size for the {1, P} (open circles), {2, P} (filled circles) and {1, 2, P} (open triangles). Figure 2E shows the PAI for the {1, 3, P} (open circles) and {2, 4, P} (filled circles) combinations when pairwise LD between SNPs 1 and 3 and SNPs 2 and 4 were varied. The error bars in Figures 2B-E represent the 95th percentile and 5th percentile values. Figure 2F shows the power of the KWII as a function of effect size for the {1, P} (open circles), {2, P} (filled circles) and {1, 2, P} (open triangles) combinations.