Figure 11
Relationship between caloric restriction and aging. Gene ontology biological process terms associated with genes up regulated by aging across all mouse tissues. A total of 2554 genes were identified as significantly increased by aging across the 22 mouse tissue types, based upon stringent significance criteria (P u < 0.001 and up regulated by age in at least five mouse tissues). Among these genes, significantly over-represented gene ontology (GO) biological process terms were identified (P < 0.05; hypergeometric test). These significant GO terms are shown in the chart and have been clustered according to the number of ancestor terms shared between any two GO biological processes. For each term, a subset of n associated genes was identified, and among these n genes, the correlation (r) between the transcriptional effects of CR and aging was evaluated. Transcriptional effects of CR and aging across tissues were defined as explained in Figure 7. For terms displayed in red font, the transcriptional association between CR and aging was negative (r < 0) and significant (P < 0.05). For terms displayed in blue font, the transcriptional association between CR and aging effects was positive (r > 0) and significant (P < 0.05). For all other terms (black font), there was no significant relationship between transcriptional effects of CR and aging (P > 0.05).