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Table 3 RNR annotation

From: RNRdb, a curated database of the universal enzyme family ribonucleotide reductase, reveals a high level of misannotation in sequences deposited to Genbank

Correct class

Correct role

Correct function

Single domain

N

Percent

Yes

Yes

Yes

NA

1702

23

Yes

No

Yes

NA

569

8

No

Yes

NA

NA

2339

32

No

No

Yes

NA

1185

16

No

No

Almosta

NA

196

3

No

No

No

Yes

105

1

No

No

No

No

1155

16

Sums

  

7251

100

  1. GenBank definitions of proteins in RNRdb. Four different aspects of RNR functional annotation have been investigated: RNR class, protein role (subunit identity), general function (involved with ribonucleotides) and single domain identification (the ATP cone [35] that regulates activity in many enzymatic subunits). Only NCBI entries for full-length sequences were used, and nine sequences that were difficult to classify were excluded. NA, not applicable.
  2. a Proteins annotated such that they contain the string "ribonucl" for all RNR proteins, or "repressor" for NrdR, but not a full description of the function such that they would classify as correctly functionally annotated, have been classified as almost correctly annotated with respect to function.