Figure 4

Overview of 12 TFs and their regulatory effect on miRNA. The figure presents a heat-map, with miRNA on the x-axis and TFs on the y-axis. The TF names on the y-axis are composed of the Entrez Gene symbol and Entrez Gene identifier, separated by "_". A coloured dot indicates the value of the PCC in expression between a TF and a mature miRNA where the TF has been predicted to regulate the corresponding miRNA. The figure only shows associations from the top quartile of associations with highest PCC. A white dot in the figure does not necessarily indicate a non-association. A possible association would have a PCC that prevented its inclusion in the top associations and is thus not shown. Furthermore, only TFs are shown that have been identified to play a central role in regulating miRNAs in the differentiation process. The heat-map has been clustered using hierarchical clustering with average linkage and Euclidian distance as the distance measure.