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Figure 5 | BMC Genomics

Figure 5

From: Identification of novel aspartic proteases from Strongyloides ratti and characterisation of their evolutionary relationships, stage-specific expression and molecular structure

Figure 5

Protein sequence alignment between S. ratti ASP-2A and the principal templates used in its modelling. Alignment of ASP-2A with the principal templates used in its modelling, human pepsin in complex with pepstatin (PDB code 1pso; [44]) and mouse renin bound to the decapeptide inhibitor CH-66 (1smr; [45]). Shading indicates the degree of sequence similarity at each position. For the Cys-rich region, Cys residues are numbered and secondary structure predicted (using PSIPRED [53]; red indicates α-helices) on lines below the alignment. Where only a single one of these two templates was used, the excluded template region is shown in light grey text. Boxed regions of ASP-2A indicate portions modelled using additional templates, Candida albicans aspartic proteinase 3 (PDB code 2h6t; [46]) for residues 247-249 and human renin (PDB code 1hrn; [47]) for residues 308-311 (see Materials and Methods). The figure was produced with Jalview [39].

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BMC Genomics

ISSN: 1471-2164

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