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Table 5 Spearman's rank correlations of heterozygosity with microsatellite sequence properties and measures of variation across individuals

From: Sequence determinants of human microsatellite variability

  1 STR region 2 STR regions 3 STR regions
  Di Tri Tetra Di Tri Tetra Tetra
Number of loci 30 133 325 10 15 97 12
Sequence properties        
   G/C content of flanking sequence 0.247 0.037 -0.034 0.237 0.291 0.142 0.035
   Number of nucleotides separating STR regions - - - 0.140 0.568 0.032 0.252
Measures of variation across individuals        
   Number of distinct alleles 0.424 0.431 0.517 0.628 0.497 0.596 0.644
   Variance in number of repeats 0.325 0.502 0.800 0.636 0.750 0.779 0.846
   Range of number of repeats 0.151 0.326 0.492 0.646 0.304 0.672 0.681
   Mean PCR fragment size 0.040 0.007 -0.016 -0152 0.571 0.126 0.308
   Mean number of repeats 0.564 0.239 0.134 0.455 0.018 0.388 0.503
   Maximum number of repeats 0.465 0.228 0.384 0.669 0.235 0.562 0.706
   Minimum number of repeats 0.335 -0.036 -0.044 0.049 -0.079 -0.036 0.385
  1. Spearman's rank correlation coefficients (ρ) are shown for comparisons of microsatellite heterozygosity with continuous microsatellite sequence properties and with measures of variation across individuals in the HGDP-CEPH data set. Microsatellites were classified by the number of separate STR regions embedded in their sequence and by their repeat unit size. Hyphens indicate comparisons that were not evaluated. For three STR regions, no comparisons were performed for di-nucleotide and tri-nucleotide loci because of small sample size (3 and 2, respectively). Correlations with P < 0.05 are highlighted in bold.