Skip to main content

Table 2 The 92 annotated genes in piglet spleen following HPS infectiona

From: Understanding Haemophilus parasuis infection in porcine spleen through a transcriptomics approach

Functional classification

Gene Discriptionb

GenBank ID

FCc

p-valued

Inflammatory response

Resistin

NM_020415

25.9

2.70E-02

 

S100 calcium binding protein A9

NM_002965

21.8

1.60E-03

 

S100 calcium binding protein A12

NM_005621

16.6

1.29E-02

 

S100 calcium binding protein A8

NM_002964

8.4

2.29E-02

 

Chitinase 3-like 1

NM_001276

6.3

1.45E-02

 

Calpain; small subunit 1

NM_001003962

5.7

2.50E-03

 

Interleukin 1 receptor accessory protein

NM_002182

4.6

6.00E-04

 

Complement component 3

NM_000064

3.3

4.51E-02

 

Solute carrier family 2, member 3

NM_006931

3.3

4.05E-02

 

Interleukin 10 receptor; beta

NM_000628

2.8

3.47E-02

 

ADAM metallopeptidase with thrombospondin type 1 motif 1

NM_006988

2.6

2.24E-02

 

Histone deacetylase 9

NM_014707

0.5

7.00E-04

 

Chemokine (C-C motif) ligand 5

NM_002985

0.4

3.30E-03

Acute-phase response

Serum amyloid A1

NM_000331

23.9

1.35E-02

 

Lactotransferrin

NM_002343

13.0

2.26E-02

 

Angiotensinogen

NM_000029

10.2

6.50E-03

 

Haptoglobin

NM_005143

10.0

1.36E-02

 

Ceruloplasmin/ferroxidase

NM_000096

4.9

4.09E-05

Humoral immune response

CD163 antigen

NM_203416

4.6

3.56E-02

 

Extracellular matrix protein 1

NM_004425

2.7

9.90E-03

 

Lysozyme

NM_000239

2.3

4.20E-03

 

CD2 (cytoplasmic tail) binding protein 2

NM_006110

0.4

2.79E-02

Cell differentiation

Transglutaminase 1

NM_000359

22.3

1.62E-02

 

Membrane-spanning 4-domains; subfamily A; member 8B

NM_031457

20.5

1.61E-02

 

Cystatin A

NM_005213

13.1

3.78E-02

 

Serpin peptidase inhibitor, clade E, member 2

NM_006216

3.6

2.74E-02

 

Secreted frizzled-related protein 1

NM_003012

2.3

3.23E-02

 

Growth arrest and DNA-damage-inducible; gamma

NM_006705

2.0

2.79E-02

 

Carnitine deficiency-associated; expressed in ventricle 1

NM_014055

0.4

2.24E-02

 

Myeloid leukemia factor 1

NM_022443

0.4

1.61E-02

 

Stathmin-like 2

NM_007029

0.2

4.11E-02

 

Mal; T-cell differentiation protein

NM_022438

0.2

2.82E-02

Cell adhesion

Claudin 3

NM_001306

9.7

2.34E-02

 

Chondroitin sulfate proteoglycan 2/versican

NM_004385

9.3

7.50E-03

 

Lectin, galactoside-binding, soluble, 8

NM_006499

2.8

7.10E-03

 

CD44 antigen

NM_001001392

2.5

5.50E-03

 

Immunoglobulin superfamily containing leucine-rich repeat

NM_201526

2.3

3.44E-02

 

Discs; large homolog 5

NM_004747

2.2

2.05E-02

 

Thrombospondin 1

NM_003246

2.2

3.49E-02

 

Collagen; type XV; alpha 1

NM_001855

2.0

1.03E-02

 

Nephronophthisis 1

NM_000272

0.5

2.18E-02

 

Nuclear receptor subfamily 3; group C; member 2

NM_000901

0.4

3.18E-02

 

Fibronectin leucine rich transmembrane protein 3

NM_198391

0.4

3.62E-02

 

PDZ domain containing 2

NM_178140

0.3

8.10E-03

Response to oxidative stress

Superoxide dismutase 2; mitochondrial

NM_000636

3.8

6.10E-03

 

Dual specificity phosphatase 1

NM_004417

2.1

2.05E-02

Homeostasis

Transcobalamin I

NM_001062

17.7

3.06E-02

 

Solute carrier organic anion transporter family, member 2A1

NM_005630

3.0

5.00E-04

 

ATP-binding cassette, sub-family A (ABC1), member 5

NM_018672

2.6

2.48E-02

Transcription factor

Zinc finger and BTB domain-containing protein 16

Q05516

5.6

9.20E-03

 

CCAAT/enhancer binding protein (C/EBP), delta

NM_005195

4.7

4.59E-02

 

Solute carrier family 39 (zinc transporter), member 14

NM_015359

4.5

3.66E-02

 

CCAAT/enhancer binding protein (C/EBP), beta

NM_005194

3.1

3.00E-02

 

Nuclear factor; interleukin 3 regulated

NM_005384

2.3

4.70E-03

Response to wounding

Macrophage stimulating 1

NM_020998

2.9

3.31E-02

 

Coagulation factor III

NM_001993

2.8

1.74E-02

 

Annexin A8

NM_001630

2.4

4.19E-02

 

Coagulation factor XIII; A1 polypeptide

NM_000129

2.4

4.59E-02

Other responses to stimulus

GTP binding protein overexpressed in skeletal muscle

NM_181702

3.6

1.73E-02

 

Period homolog 1

NM_002616

2.6

7.50E-03

 

Interleukin 4 receptor

NM_000418

2.2

2.57E-02

 

Major histocompatibility complex; class II; DR beta 1

NM_002124

0.5

4.18E-02

 

Guanylate binding protein 1; interferon-inducible; 67 kDa

NM_002053

0.5

8.70E-03

 

DnaJ

NM_012266

0.5

3.60E-03

 

Pituitary tumor-transforming 1

NM_004219

0.5

5.00E-04

 

Potassium voltage-gated channel; subfamily H

NM_172057

0.5

4.33E-02

 

Major histocompatibility complex; class I; B

NM_005514

0.3

6.00E-04

Development

Cofilin 1

NM_005507

19.4

3.18E-02

 

P8 protein

NM_012385

5.4

1.57E-02

 

Neuron navigator 1

NM_020443

3.4

1.92E-02

 

apolipoprotein D

NM_001647

2.6

8.00E-03

 

Protein tyrosine phosphatase; non-receptor type 1

NM_002827

2.3

4.58E-02

 

Putative insulin-like growth factor II associated prote

NM_001007139

2.2

2.60E-03

 

FYVE; RhoGEF and PH domain containing 4

NM_139241

2.2

4.74E-02

 

Slingshot homolog 2

NM_033389

2.2

3.00E-04

 

3-phosphoadenosine 5-phosphosulfate synthase 2

NM_001015880

2.1

2.89E-02

 

Epimorphin

NM_194356

0.5

4.16E-02

 

Chondrolectin

NM_024944

0.5

2.66E-02

 

Ecotropic viral integration site 5

NM_005665

0.5

1.52E-02

 

SMAD; mothers against DPP homolog 5

NM_001001419

0.5

4.20E-02

 

Stearoyl-CoA desaturase

NM_005063

0.5

1.16E-02

 

Ankyrin 3, node of Ranvier

NM_001149

0.5

9.40E-03

 

Insulin-like growth factor 2

NM_000612

0.4

1.76E-02

 

SRY

NM_003108

0.4

4.06E-02

 

Chromosome 11 open reading frame 8

NM_001584

0.4

3.25E-02

 

Actin; alpha; cardiac muscle

NM_005159

0.3

8.10E-03

 

Cellular retinoic acid binding protein 1

NM_004378

0.1

4.34E-02

 

Erythroid associated factor

NM_016633

0.01

6.70E-03

Urea cycle

Arginase; type II

NM_001172

2.1

1.41E-02

 

Arginase; type I

NM_000045

0.2

2.53E-02

Organismal physiological process

v-maf musculoaponeurotic fibrosarcoma oncogene homolog F

NM_152878

5.2

2.00E-04

 

Uridine phosphorylase 1

NM_181597

4.4

1.94E-02

  1. aUp/down-regulated genes which putative functions assigned based on GO term and manual annotation. Manual annotations were listed in italics. Many genes could be classified into multiple categories but only the most specific biology processes were listed. bTop informative BLASTX hit. cFold change, gene expression level following infection compared to the control. "≥2" represents up regulation (infection/control), "≤0.5" represents down regulation. d Significance level of differential expression for a particular gene.
Back to article page

BMC Genomics

ISSN: 1471-2164

Contact us