A genomic glimpse of aminoacyl-tRNA synthetases in malaria parasite Plasmodium falciparum

BMC Genomics

Table 2 Transcriptomic and proteomic data for aaRSs in P. falciparum@

ID	*aaRS*	mean1 asex	mean2 asex	Gam	spor	TG^§	T	Me	G	Sp	Me*	Oocyst/Spor*
MAL13P1.281	AP-GluRs	4.8	10.9	39.7	6.5
PF08_0011	AP-LeuRs	51.4	59.1	85.4	371.6					+
PF10_0053	AP-MetRs	18.7	16.5	19	19
PF11_0181	AP-TyrRs	13.2	2.6	0	0
PF14_0166	AP-LysRs	60.3	48.0	166.4	48.3
PFE0475w	AP-AsnRs	104.6	92.5	222.8	149.6		+
PFE0715w	AP-AspRs	17.2	26.3	21.1	0					+
PFI0680c	AP-ArgRs	15.7	17.9	34.7	1.1
PFI1240c	AP-ProRs	10.8	14.0	19.9	4.2
PFI1645c	AP-HisRs	27.4	21.2	8.7	15		+
PFL0770w	AP-SerRs	117.6	110.9	431.3	69
PFL1210w	AP-IleRs	124.0	109.5	132.3	71			+
PFL1540c	AP-PheRs	13.7	9.7	6	0.1
mean		44.6	41.5	91.3	58.1
PF11_0270	ThrRs	580.0	582.1	181.2	154.6	+	+	+	+	+	+	+
PF13_0354	AlaRs	123.6	129.9	75.5	27.5	+					+	+
PF10_0149	CysRs	138.1	115.6	29.6	44.5	+						+
MAL8P1.125	TyrRs	225.6	260.0	134.3	259.2	+	+	+	+	+	+	+
PF07_0073	SerRs	190.9	193.8	364.2	22.5	+		+				+
PF10_0340	MetRs	389.3	387.5	479.9	3.4	+	+	+			+	+
PF11_0051	PheRs	126.2	126.5	46.9	1.6	+	+
PF13_0170	GlnRs	558.8	570.8	272.3	214.7	+		+
PF13_0179	IleRs	192.1	188.1	152.8	0	+	+	+	+	+	+	+
PF13_0205	TrpRs	112.6	189.4	42.8	171.8	+			+
PF13_0257	GluRs	330.0	334.5	205.6	139	+	+	+	+		+	+
PF13_0262	LysRs	1048.8	971.6	591	281.9	+	+	+	+	+	+	+
PF14_0198	GlyRs	93.4	80.1	102.4	0	+	+	+			+	+
PF14_0428	HisRs	35.4	51.1	0	0	+		+			+
PF14_0589	ValRs	48.0	33.2	5.8	0	+		+		+	+	+
PFA0145c	AspRs	359.2	359.2	361	21.4	+	+	+
PFA0480w	PheRs	49.5	20.2	28.4	10.4	+		+			+
PFB0525w	AsnRs	575.3	686.7	493.1	106.2	+	+	+	+		+	+
PFL0670c	ProRs	105.4	108.8	50.	5 0		+	+	+	+	+	+
PFL0900c	ArgRs	118.3	120.8	37.1	76.2	+	+	+		+	+
PFL2485c	TrpRs	38.2	51.1	16.5	15.9
Mean		259.0	264.8	174.8	73.8

^@ Gene expression data are by Le Roch[52]. Mean1 and mean2 asex refer to mean values of mRNA abundance along asexual stages synchronized by sorbitol and by temperature respectively. In the last two columns, mass spectrometry data from purified merozoites (Me*; Leiden Malaria Group, unpublished data) and mosquito stages (Oocyst/Spor*; oocysts, oocystderived sporozoites and salivary gland sporozoites from Anopheles stephensi infected with NF54 strain of P. falciparum) are shown.
TG^§ proteomic data are obtained by Trophozoites, Gametocytes early and Gametocytes late by Lasonder lab. [88]. T (trophozoites), Me (merozoites), G (gametocytes), Sp (sporozoites) columns refer to data by multi-dimensional protein identification technology in four stages of the parasite life cycle.

ISSN: 1471-2164