Table 3 Structural differences between tyrosyl-tRNA synthetases from human & P. falciparum
From: A genomic glimpse of aminoacyl-tRNA synthetases in malaria parasite Plasmodium falciparum
| Â | Hs-TyrRS (2PID)* | Pf-TyrRS(PF11_0181) @ | Hs-TyrRS (1N3L) ! | Pf-TyrRS (MAL8P1.125) $ |
|---|---|---|---|---|
Motif 1 | HVGH | HLGN | HAVY | HIAQ |
Motif 2 | KLGKS | KYSKS | KMSSS | KMSKS |
Residues involved in tyrosine and A73 recognition | Ser200 | Arg229 | Gly46 | Gly67 |
| Â | Gln202 | Glu231 | Arg93 | Val116 |
| Â | Met252 | Gln279 | Ala340 | Lys370 |
| Â | Ile274 | Leu301 | Tyr341 | Val371 |
Insertions | ---- | Arg157-Glu175 | Â | Â |
| Â | ---- | Glu316-Leu321 | Met104-Ser107 | Glu142-Lys146 |
| Â | ---- | Asn369-Lys422 | Â | Asn356-Lys360 |