Figure 1
From: Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice
Significance analysis of microarrays. The SAM plots represent the differentially expressed genes of mono-transgenic (A and B with FDR 0.5), and double-transgenic mice (C and D with FDR 0.0). The Delta parameter, represented by red lines, defines the significance field (-1.72/+2.23 (A: ADAM10 versus FVB/N), -1.36/+1.43 (B: dnADAM10 versus FVB/N), -1.56/+2.06 (C: ADAM10/APP[V717I] versus APP[V717I]), -2.85/+3.29 (D: dnADAM10/APP[V717I] versus APP[V717I])). Shown above the upper line are the genes upregulated significantly, and below the lower line the genes downregulated significantly.