Figure 3
From: Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice
Heat map representing the clustering of genes in mono- and double transgenic mice. A) ADAM10, dnADAM10 and FVB/N mice; B) AD10/APP[V717I], dnAD10/APP[V717I], and APP[V717I] mice. Selected significantly regulated genes on individual chips are shown. The upper graph (I) represents the hierarchical clustering, the colored scales (II) the difference in gene expression. Unsupervised cluster analysis showed that the expression profiles of mono-transgenic mouse genes (A) cluster according to the experimental conditions. In case of double-transgenic mice (B), cluster analysis revealed a more rough agreement in the discrimination of gene expression with experimental groups. The blue (lower expression) to red (higher expression) color scale indicates 2-based logarithms of the mean expression values of the single probes after ChipInspector normalization (Genomatix, Munich, Germany).