Figure 5
From: Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice
Alzheimer disease genes in mono- and double-transgenic mice. Differentially expressed genes of ADAM10 versus FVB/N with FDR 0.5 (355 genes), of dnADAM10 versus FVB/N with FDR 0.5 (143 genes), of ADAM10/APP[V717I] versus APP[V717I] with FDR 0.0 (592 genes) and of dnADAM10/APP[V717I] versus APP[V717I] with FDR 0.0, restricted to 300 up- and 300 downregulated genes (600 genes), were compared to AD genes (934 genes) from GeneCards (Weizmann Institute of Science, Version 2.36). In ADAM10 versus FVB/N 25 AD genes (7% of 355 genes), in dnADAM10 versus FVB/N 13 AD genes (9% of 143 genes), in ADAM10/APP[V717I]versus APP[V717I] 43 AD genes (7% of 592 genes) and in dnADAM10/APP[V717I] versus APP[V717I] 30 AD genes (5% of 600 genes) were found.