Figure 7
From: Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice
Venn diagram of regulated genes in investigated mouse lines after CARMA-analysis (BH<0.005). Venn diagram of APP[V717I]versus FVB/N (A), ADAM10/APP[V717I] versus ADAM10 (B) und dnADAM10/APP[V717I] versus dnADAM10 (C), generated by a custom-written Perl-script showing the effect of APP[V717I] overexpression in double-transgenic mice. The numbers in the spaces of overlapping circles represent the number of transcripts that were affected in all mouse groups. The numbers in the outer portion of each circle represent the number of transcripts that were exclusively affected in two mouse groups.