Table 6 Significantly regulated genes in double-transgenic ADAM10/APP[V717I] mice in relation to mono-transgenic APP[V717I] mice
From: Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice
Gene ID | Gene symbol | Description | Fold change | log ratio | d-value | Functional groups |
|---|---|---|---|---|---|---|
56215 | Acin1 | apoptotic chromatin condensation inducer 1 | 0.795 | -0.331 | -1.955 | cell communication; cell death |
329910 | Acot11 | acyl-CoA thioesterase 11 | 0.812 | -0.301 | -1.620 | cell communication |
432530 | Adcy1 | adenylate cyclase 1 | 0.810 | -0.304 | -1.880 | cell communication; receptor binding and activity |
68465 | Adipor2 | adiponectin receptor 2 | 0.781 | -0.357 | -1.868 | cell communication |
11540 | Adora2a | adenosine A2a receptor | 1.294 | 0.372 | 2.210 | cell communication; synapse |
11735 | Ank3 | ankyrin 3, epithelial | 1.344 | 0.427 | 2.159 | cell communication; nervous system development; synapse |
11787 | Apbb2 | amyloid beta (A4) precursor protein-binding, family B, member 2 | 0.788 | -0.344 | -2.018 | cell communication; cell death; nervous system development |
226548 | Aph1a | anterior pharynx defective 1a homolog (C. elegans) | 0.807 | -0.309 | -1.879 | cell communication |
76117 | Arhgap15 | Rho GTPase activating protein 15 | 1.275 | 0.351 | 2.139 | cell communication |
76294 | Asb5 | ankyrin repeat and SOCs box-containing protein 5 | 1.254 | 0.327 | 2.079 | cell communication |
98660 | Atp1a2 | ATPase, Na+/K+ transporting, alpha 2 polypeptide | 0.820 | -0.287 | -1.746 | cell communication; synapse |
12043 | Bcl2 | B-cell leukemia/lymphoma 2 | 0.815 | -0.295 | -1.741 | cell communication; cell death |
72567 | Bclaf1 | BCL2-associated transcription factor 1 | 1.326 | 0.407 | 2.183 | cell death |
12122 | Bid | BH3 interacting domain death agonist | 1.291 | 0.369 | 2.278 | cell death |
109880 | Braf | Braf transforming gene | 0.812 | -0.301 | -1.837 | cell communication |
12227 | Btg2 | B-cell translocation gene 2, anti-proliferative | 1.342 | 0.424 | 2.357 | cell death |
12300 | Cacng2 | calcium channel, voltage-dependent, gamma subunit 2 | 0.803 | -0.316 | -1.872 | cell communication |
12325 | Camk2g | calcium/calmodulin-dependent protein kinase II gamma | 0.810 | -0.304 | -1.711 | receptor binding and activity |
12319 | Car8 | carbonic anhydrase 8 | 0.785 | -0.349 | -1.679 | cell communication |
12361 | Cask | calcium/calmodulin-dependent serine protein kinase (MAGUK family) | 0.832 | -0.265 | -1.689 | receptor binding and activity; synapse |
226751 | Cdc42bpa | Cdc42 binding protein kinase alpha | 1.288 | 0.365 | 2.130 | cell communication |
12575 | Cdkn1a | cyclin-dependent kinase inhibitor 1A (P21) | 0.779 | -0.36 | -2.004 | cell death |
235415 | Cplx3 | complexin 3 | 1.276 | 0.352 | 2.294 | cell communication; synapse |
12955 | Cryab | crystallin, alpha B | 0.744 | -0.427 | -2.161 | cell communication |
12977 | Csf1 | colony stimulating factor 1 (macrophage) | 0.822 | -0.282 | -1.717 | cell adhesion; cell communication; receptor binding and activity |
27373 | Csnk1e | casein kinase 1, epsilon | 0.791 | -0.338 | -2.160 | cell communication |
13000 | Csnk2a2 | casein kinase 2, alpha prime polypeptide | 0.801 | -0.321 | -1.909 | cell communication |
16007 | Cyr61 | cysteine rich protein 61 | 1.298 | 0.376 | 2.213 | receptor binding and activity |
54722 | Dfna5h | deafness, autosomal dominant 5 homolog (human) | 0.803 | -0.316 | -1.714 | cell communication |
330938 | Dixdc1 | DIX domain containing 1 | 0.825 | -0.278 | -1.770 | cell communication |
50768 | Dlc1 | deleted in liver cancer 1 | 0.794 | -0.332 | -1.894 | cell communication |
13430 | Dnm2 | dynamin 2 | 0.815 | -0.295 | -2.004 | synapse |
13527 | Dtna | dystrobrevin alpha | 1.271 | 0.346 | 2.240 | synapse |
13841 | Epha7 | Eph receptor A7 | 1.300 | 0.379 | 2.146 | cell communication; nervous system development |
14254 | Flt1 | FMS-like tyrosine kinase 1 | 0.787 | -0.345 | -2.064 | cell communication |
118446 | Gje1 | gap junction membrane channel protein epsilon 1 | 1.349 | 0.432 | 2.453 | cell communication; |
69367 | Glrx2 | glutaredoxin 2 (thioltransferase) | 1.252 | 0.324 | 2.066 | cell communication; cell death |
14682 | Gnaq | guanine nucleotide binding protein, alpha q polypeptide | 0.813 | -0.298 | -1.776 | cell communication; nervous system development;synapse |
224792 | Gpr116 | G protein-coupled receptor 116 | 1.279 | 0.355 | 2.154 | cell communication |
14799 | Gria1 | glutamate receptor, ionotropic, AMPA1 (alpha 1) | 0.776 | -0.365 | -1.975 | synapse |
14800 | Gria2 | glutamate receptor, ionotropic, AMPA2 (alpha 2) | 0.740 | -0.435 | -1.907 | cell communication; synapse |
14804 | Grid2 | glutamate receptor, ionotropic, delta 2 | 0.806 | -0.312 | -1.793 | synapse |
14943 | Gzmf | granzyme F | 0.801 | -0.321 | -1.928 | cell death |
15258 | Hipk2 | homeodomain interacting protein kinase 2 | 0.761 | -0.394 | -2.283 | cell communication; cell death |
26557 | Homer2 | homer homolog 2 (Drosophila) | 0.774 | -0.37 | -2.144 | cell communication |
14828 | Hspa5 | heat shock 70 kD protein 5 (glucose-regulated protein) | 0.716 | -0.481 | -1.984 | cell communication; cell death |
56213 | Htra1 | HtrA serine peptidase 1 | 0.795 | -0.331 | -1.834 | cell communication; receptor binding and activity |
15951 | Ifi204 | interferon activated gene 204 | 1.268 | 0.343 | 2.104 | cell death |
16323 | Inhba | inhibin beta-A | 0.718 | -0.477 | -2.551 | cell death; receptor binding and activity |
241226 | Itga8 | integrin alpha 8 | 1.270 | 0.345 | 2.112 | cell adhesion; cell communication |
16419 | Itgb5 | integrin beta 5 | 0.832 | -0.265 | -1.649 | cell adhesion; cell communication |
16443 | Itsn1 | intersectin 1 (SH3 domain protein 1A) | 0.826 | -0.275 | -1.839 | cell communication |
22343 | Lin7c | lin-7 homolog C (C. elegans) | 0.831 | -0.267 | -1.652 | cell communication; synapse |
330814 | Lphn1 | latrophilin 1 | 0.803 | -0.316 | -1.934 | cell communication |
16998 | Ltbp3 | latent transforming growth factor beta binding protein 3 | 1.291 | 0.368 | 2.202 | cell communication; receptor binding and activity |
17762 | Mapt | microtubule-associated protein tau | 0.727 | -0.459 | -2.312 | nervous system development |
17118 | Marcks | myristoylated alanine rich protein kinase C substrate | 0.799 | -0.324 | -1.815 | receptor binding and activity |
13728 | Mark2 | MAP/microtubule affinity-regulating kinase 2 | 0.817 | -0.291 | -1.922 | cell communication |
17193 | Mbd4 | methyl-CpG binding domain protein 4 | 0.818 | -0.289 | -1.753 | cell death |
52065 | Mfhas1 | malignant fibrous histiocytoma amplified sequence 1 | 0.759 | -0.398 | -2.297 | cell communication |
59030 | Mkks | McKusick-Kaufman syndrome protein | 0.749 | -0.416 | -2.427 | cell communication |
17346 | Mknk1 | MAP kinase-interacting serine/threonine kinase 1 | 1.273 | 0.348 | 2.113 | cell communication |
17748 | Mt1 | metallothionein 1 | 0.807 | -0.31 | -1.974 | cell communication |
17750 | Mt2 | metallothionein 2 | 0.780 | -0.359 | -2.141 | cell communication |
17909 | Myo10 | myosin X | 0.824 | -0.28 | -1.751 | cell communication |
17918 | Myo5a | myosin Va | 1.309 | 0.389 | 2.105 | cell communication; receptor binding and activity; synapse |
17984 | Ndn | necdin | 1.315 | 0.395 | 2.209 | cell communication; nervous system development |
192167 | Nlgn1 | neuroligin 1 | 1.381 | 0.466 | 2.470 | cell communication; nervous system development; synapse |
18125 | Nos1 | nitric oxide synthase 1, neuronal | 0.795 | -0.331 | -1.953 | cell communication; receptor binding and activity; synapse |
225872 | Npas4 | neuronal PAS domain protein 4 | 1.355 | 0.438 | 2.375 | cell communication |
18212 | Ntrk2 | neurotrophic tyrosine kinase, receptor, type 2 | 0.797 | -0.327 | -1.978 | cell communication; synapse |
18378 | Omp | olfactory marker protein | 0.790 | -0.34 | -1.907 | cell communication |
18389 | Oprl1 | opioid receptor-like 1 | 1.330 | 0.411 | 2.066 | cell communication |
18577 | Pde4a | phosphodiesterase 4A, cAMP specific | 0.812 | -0.301 | -1.903 | cell communication |
18578 | Pde4b | phosphodiesterase 4B, cAMP specific | 0.812 | -0.301 | -1.586 | cell communication |
18583 | Pde7a | phosphodiesterase 7A | 0.830 | -0.268 | -1.656 | cell communication |
14827 | Pdia3 | protein disulfide isomerase associated 3 | 0.812 | -0.3 | -1.829 | cell death |
74055 | Plce1 | phospholipase C, epsilon 1 | 0.807 | -0.309 | -1.923 | cell communication |
67916 | Ppap2b | phosphatidic acid phosphatase type 2B | 0.784 | -0.351 | -2.088 | cell communication |
170826 | Ppargc1b | peroxisome proliferative activated receptor, gamma, coactivator 1 beta | 0.749 | -0.417 | -2.262 | cell communication |
333654 | Ppp1r13l | protein phosphatase 1, regulatory (inhibitor) subunit 13 like | 0.820 | -0.287 | -1.903 | cell death |
73728 | Psd | pleckstrin and Sec7 domain containing | 1.291 | 0.368 | 2.130 | cell communication |
19246 | Ptpn1 | protein tyrosine phosphatase, non-receptor type 1 | 0.754 | -0.407 | -2.217 | cell communication |
19268 | Ptprf | protein tyrosine phosphatase, receptor type, F | 0.815 | -0.296 | -1.789 | cell communication |
19334 | Rab22a | RAB22A, member RAS oncogene family | 0.817 | -0.292 | -1.773 | cell communication |
19337 | Rab33a | RAB33A, member of RAS oncogene family | 1.276 | 0.352 | 2.165 | cell communication |
19340 | Rab3d | RAB3D, member RAS oncogene family | 0.792 | -0.337 | -1.964 | cell communication |
19415 | Rasal1 | RAS protein activator like 1 (GAP1 like) | 1.312 | 0.392 | 2.203 | cell communication |
17252 | Rdh11 | retinol dehydrogenase 11 | 1.300 | 0.378 | 2.172 | cell communication |
56533 | Rgs17 | regulator of G-protein signaling 17 | 1.309 | 0.388 | 2.141 | cell communication |
56470 | Rgs19 | regulator of G-protein signaling 19 | 1.275 | 0.35 | 2.124 | cell communication |
19893 | Rpgr | retinitis pigmentosa GTPase regulator | 1.322 | 0.403 | 2.232 | cell communication |
77945 | Rpgrip1 | retinitis pigmentosa GTPase regulator interacting protein 1 | 0.784 | -0.351 | -1.946 | cell communication |
110876 | Scn2a1 | sodium channel, voltage-gated, type II, alpha 1 | 0.798 | -0.325 | -1.848 | cell communication; cell death |
58234 | Shank3 | SH3/ankyrin domain gene 3 | 0.779 | -0.361 | -2.189 | cell communication; cell death |
27401 | Skp2 | S-phase kinase-associated protein 2 (p45) | 1.278 | 0.354 | 2.111 | cell death |
65962 | Slc9a3r2 | solute carrier family 9 (sodium/hydrogen exchanger), isoform 3 regulator 2 | 0.816 | -0.293 | -1.665 | cell communication |
17128 | Smad4 | MAD homolog 4 (Drosophila) | 0.802 | -0.318 | -1.838 | cell communication |
20411 | Sorbs1 | sorbin and SH3 domain containing 1 | 0.779 | -0.361 | -1.938 | cell adhesion; cell communication |
20692 | Sparc | secreted acidic cysteine rich glycoprotein | 0.756 | -0.403 | -2.405 | cell communication |
114715 | Spred1 | sprouty protein with EVH-1 domain 1, related sequence | 0.796 | -0.329 | -1.928 | cell communication |
114716 | Spred2 | sprouty-related, EVH1 domain containing 2 | 0.776 | -0.365 | -1.933 | cell communication |
14270 | Srgap2 | SLIT-ROBO Rho GTPase activating protein 2 | 0.825 | -0.278 | -1.778 | cell communication |
20848 | Stat3 | signal transducer and activator of transcription 3 | 0.808 | -0.308 | -1.710 | cell communication |
20913 | Stxbp4 | syntaxin binding protein 4 | 0.786 | -0.347 | -2.069 | cell communication |
240725 | Sulf1 | sulfatase 1 | 0.833 | -0.264 | -1.811 | cell death |
104015 | Synj1 | synaptojanin 1 | 1.366 | 0.45 | 2.207 | cell communication; synapse |
24071 | Synj2bp | synaptojanin 2 binding protein | 0.752 | -0.411 | -2.093 | cell communication |
21415 | Tcf3 | transcription factor 3 | 0.799 | -0.323 | -1.978 | cell communication |
21416 | Tcf7l2 | transcription factor 7-like 2, T-cell specific, HMG-box | 1.352 | 0.435 | 2.231 | cell communication |
110595 | Timp4 | tissue inhibitor of metalloproteinase 4 | 0.797 | -0.328 | -1.646 | cell communication; synapse |
22031 | Traf3 | Tnf receptor-associated factor 3 | 0.812 | -0.3 | -1.800 | cell communication; cell death |
94090 | Trim9 | tripartite motif protein 9 | 0.759 | -0.397 | -1.905 | cell communication; synapse |
22421 | Wnt7a | wingless-related MMTV integration site 7A | 0.827 | -0.274 | -1.758 | cell communication; nervous system development; synapse |
78889 | Wsb1 | WD repeat and SOCS box-containing 1 | 1.288 | 0.365 | 2.069 | cell communication |
22627 | Ywhae | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide | 1.319 | 0.399 | 2.098 | cell communication |
235320 | Zbtb16 | zinc finger and BTB domain containing 16 | 0.776 | -0.366 | -1.759 | cell death |