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Table 4 Distribution of non-synonymous mutations within the predicted V1R protein structure.

From: Dynamic evolution of V1R putative pheromone receptors between Mus musculus and Mus spretus

Domain

Conserved (21)

dS/dN > 2 (6)

dS/dN < 1 (2)

E1 (23)

 

0.72

2.17

TM1 (12)

G24,N28,L31

1.39

20.83

I1 (14)

 

2.38

0.00

TM2 (22)

L60,L63

1.52

0.00

E2 (25)

D72,W80,C85,R96

1.33

2.00

TM3 (22)

L106,L114

0.00

6.82

I2 (13)

K125

1.28

0.00

TM4 (23)

Y143

5.07

2.17

E3 (39)

N159,C172,R192

0.85

2.56

TM5 (18)

L211

0.93

2.78

I3 (26)

L221,S227,A236

5.77

9.62

TM6 (20)

 

4.17

2.50

E4 (17)

R261

0.98

8.82

TM7 (16)

 

1.04

0.00

  1. The size (number of amino acid residues, brackets) of predicted domains structures (E = extracellular, I = intracellular, TM = transmembrane) and the locations of the 21 most conserved amino-acid residues in rodent V1R proteins are shown. The incidence of non-synonymous mutations in six orthologous gene pairs (MUS.A6-YUA.3, MUS.B9-YUA.4, MUS.B4-YUB.4, MUS.A2-YUB.6, MUS.B1-YUC.3, and MUS.A1-YUC.5) with dS/dN > 2 (presumed purifying selection) were compared to two orthologous gene pairs (MUS.A5-YUB.2 and MUS.B2-YUC.1) with dS/dN < 1 (presumed adaptive selection). Numbers shown are the incidence of occurrence (observed percent mutations/opportunities) within a particular structural domain (outliers are bolded).
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BMC Genomics

ISSN: 1471-2164

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