Somatic, germline and sex hierarchy regulated gene expression during Drosophila metamorphosis

Lebo, Matthew S; Sanders, Laura E; Sun, Fengzhu; Arbeitman, Michelle N

doi:10.1186/1471-2164-10-80

BMC Genomics

Table 3 Genes expressed downstream of DSX at 48 hour APF.

From: Somatic, germline and sex hierarchy regulated gene expression during Drosophila metamorphosis

Sex-bias	Gene Name	CG # *	Ch^†	FC^‡	Functional Annotation^ξ
Male	CG1342	CG1342	3R	6.0	serine-type endopeptidase inhibitor activity
	Osiris 11	CG15596	3R	4.9	unknown
	CG12063	CG12063	3R	4.8	unknown
	CG13535	CG13535		4.2	unknown
	SP71	CG17131	X	4.0	unknown
	CG32159	CG32159	3L	6.5	unknown
	Ecdysone-inducible gene E1	CG32356	3L	4.8	lipoprotein binding; imaginal disc eversion
	CG4386	CG4386	2R	4.5	trypsin activity; proteolysis
	miniature	CG9369	X	3.8	cuticle pattern formation; epidermal cell differentiation
	Osiris 21	CG14925	2L	3.4	unknown
	CG4702	CG4702	3R	3.3	unknown
	CG8420	CG8420	3R	3.2	unknown
	dusky-like	CG15013	3L	3.1	structural constituent of cuticle
	CG1499	CG1499	3R	3.1	unknown
	Ecdysone-inducible gene L1	CG10717	3L	3.1	unknown
	ectodermal	CG6611	3L	3.0	unknown
	vrille	CG14029	2L	3.0	transcription factor activity; bristle morphogenesis
	CG13728	CG13728	3L	2.9	unknown
	CG15020	CG15020	3L	2.8	structural constituent of cuticle
	CG15643	CG15643	X	2.8	unknown
	CG32354	CG32354	3L	2.7	endopeptidase inhibitor activity
	CG13078	CG13078	2L	2.7	unknown
	CG15589	CG15589	3R	2.7	unknown
	shavenoid	CG13209	2R	2.7	wing hair biogenesis; antennal morphogenesis
	CG10898	CG10898	3R	2.5	DNA repair
	CG13059	CG13059	3L	2.3	unknown
	CG4844	CG4844	2R	2.3	unknown
	CG31637	CG31637	2L	2.2	sulfotransferase activity; carbohydrate metabolism
	CG11438	CG11438	3L	2.1	phosphatidate phosphatase activity; lipid metabolism
	Dopa decarboxylase	CG10697	2L	2.0	catecholamine metabolism; learning and/or memory
	brother of iHog	CG32796	X	2.0	ectoderm development; nervous system development
	CG10249	CG10249	2R	2.0	unknown
Female	CG6337	CG6337	2R	15.2	cysteine-type endopeptidase activity
	CG31878	CG31878	2L	11.9	structural constituent of cuticle
	CG16884	CG16884	2L	11.0	unknown
	CG16885	CG16885	2L	10.2	unknown
	CG14752	CG14752	2R	9.0	unknown
	CG8927	CG8927	3R	7.5	unknown
	CG7330	CG7330	3L	6.7	unknown
	CG15251	CG15251	X	6.5	unknown
	CG12164	CG12164	2R	6.1	unknown
	CG10264	CG10264	3R	6.0	unknown
	Cuticular protein 97Eb	CG15884	3R	5.9	structural constituent of cuticle
	CG32694	CG32694	X	5.6	unknown
	CG16886	CG16886	2L	5.3	unknown
	b6	CG3100	X	5.2	neuronal pentraxin receptor activity
	Peritrophin A	CG17058	X	5.2	chitin binding; chitin metabolism
	CG10175	CG10175	3R	4.9	carboxylesterase activity; phosphopantetheine binding
	CG30427	CG30427	2R	4.9	oxidoreductase activity
	CG11380	CG11380	X	4.8	unknown
	CG15778	CG15778	X	4.7	unknown
	CG17829	CG17829	X	4.5	nucleic acid binding; zinc ion binding
	CG1441	CG1441	2R	4.3	oxidoreductase activity
	CG32645	CG32645	X	4.3	transferase activity
	CG32036	CG32036	3L	4.2	chitin binding; chitin metabolism
	CG14052	CG14052	X	4.1	unknown
	Cyp303a1	CG4163	2L	4.1	sensory organ development; steroid metabolism
	CG3244	CG3244	2L	4.0	sugar binding
	CG32499	CG32499	X	3.8	chitin binding; chitin metabolism
	CG32550	CG32550	X	3.7	unknown
	CG10051	CG10051	2R	3.7	unknown
	CG13931	CG13931	3L	3.6	unknown
	Pherokine 3	CG9358	2R	3.6	protein kinase activity; gametogenesis
	CG17707	CG17707	X	3.5	unknown
	CG14534	CG14534	2L	3.5	nutrient reservoir activity
	Cuticular protein 50Ca	CG13338	2R	3.5	structural constituent of cuticle
	CG13138	CG13138	2L	3.5	unknown
	CG9021	CG9021	2L	3.4	unknown
	GV1	CG12023	3L	3.4	DNA binding
	CG14770	CG14770	X	3.4	unknown
	CG15322	CG15322	X	3.3	unknown
	CG7031	CG7031	3R	3.3	unknown
	Cuticular protein 97Ea	CG6131	3R	3.3	structural constituent of cuticle
	CG14218	CG14218	X	3.3	serine-type endopeptidase activity
	CG33299	CG33299	2L	3.3	unknown
	CG17777	CG17777	X	3.2	unknown
	CG15055	CG15055	X	3.2	unknown
	CG1561	CG1561	X	3.1	unknown
	CG1702	CG1702	X	3.0	glutathione transferase activity; defense response
	CG12057	CG12057	X	2.9	unknown
	CG13616	CG13616	3R	2.9	unknown
	CG17032	CG17032	3L	2.9	unknown
	CG6592	CG6592	3L	2.9	chymotrypsin activity; proteolysis
	HDC15381	CG33342	3R	2.8	unknown
	Cuticular protein 51A	CG10112	2R	2.8	structural constituent of cuticle
	CG8192	CG8192	2R	2.8	unknown
	CG5873	CG5873	3R	2.7	peroxidase activity; defense response
	Peroxidase	CG3477	3R	2.7	peroxidase activity; phagocytosis, engulfment
	CG14946	CG14946	2L	2.6	oxidoreductase activity; binding
	LCBP1	CG8756	3L	2.6	chitin deacetylase activity; open tracheal system
	SRY interacting protein 1	CG10939	2R	2.5	cell homeostasis; ion transport; olfactory behavior
	flightin	CG7445	3L	2.5	muscle thick filament assembly
	obstructor-A	CG17052	X	2.5	chitin binding; chitin metabolism
	Gfat1	CG12449	3R	2.5	sugar binding; carbohydrate biosynthesis
	CG6739	CG6739	2L	2.5	unknown
	CG13062	CG13062	3L	2.5	unknown
	CG5506	CG5506	3L	2.4	unknown
	dpr13	CG33996	2R	2.4	unknown
	CG7047	CG7047	3L	2.4	unknown
	CG9850	CG9850	2R	2.4	metallopeptidase activity; cell proliferation
	CG30101	CG30101	2R	2.4	unknown
	omega	CG32145	3L	2.4	peptidase activity; signal transduction
	CG4404	CG4404	X	2.4	DNA binding
	lethal (2) essential for life	CG4533	2R	2.3	embryonic development; protein folding
	CG32816	CG32816	X	2.3	unknown
	CG14191	CG14191	X	2.3	unknown
	CG7135	CG7135	X	2.2	unknown
	pgant2	CG3254	2L	2.2	protein amino acid glycosylation
	CG8358	CG8358	3R	2.1	neprilysin activity; proteolysis; signal transduction
	CG12523	CG12523	3L	2.1	unknown
	melted	CG8624	3L	2.1	specific transcriptional repressor activity; development
	CG9134	CG9134	3L	2.1	sugar binding
	CG9328	CG9328	2L	2.1	unknown
	serpentine	CG32209	3L	2.1	chitin metabolism; tracheal system development
	CG4484	CG4484	3L	2.1	sucrose:hydrogen symporter activity
	CG16820	CG16820	2L	2.1	unknown
	CG9990	CG9990	3R	2.1	ATPase activity; transporter activity; ATP binding
	CG13188	CG13188	2R	2.1	unknown
	Limpet	CG32171	3L	2.0	transcription factor activity; development

All genes listed had at least a 2.0-fold difference in transcript abundance when comparing XX dsx^Dpseudomales to wild type females at 48 hour APF. For the full lists of genes regulated as a consequence of dsx, see Additional file 10. * Annotation symbol from Flybase. ^† Chromosomal arm on which the gene is located. ^‡ Fold change difference between the sexes. ^ξGO annotations for each gene as listed in Flybase.

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ISSN: 1471-2164

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