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Table 3 Set of genes commonly regulated by IL-6 and NGF in PC12 cells

From: Expression profiling and Ingenuity biological function analyses of interleukin-6- versus nerve growth factor-stimulated PC12 cells

Gene

 

Fold change

  

IL-6

NGF

Enzymes

   

   guanine nucleotide binding protein, alpha z

GNAZ

14

9

   glutathione S-transferase A3

GSTA3

- 3

- 3

   aldo-keto reductase family 1, member C1

AKR1C1

12

10

G-protein coupled receptors

   

   cholinergic receptor, muscarinic 3

CHRM3

- 3

- 2

Growth factors

   

   growth differentiation factor 15

GDF15

80

131

Ion channels

   

   glutamate receptor, ionotropic, delta 2

GRID2

91

78

   purinergic receptor P2X, ligand-gated ion channel

P2RX2

11

13

Kinases

   

   phosphatidylinositol 4-kinase beta

PI4KB

2

3

Peptidases

   

   caspase 1

CASP1

40

- 5

   proteasome subunit alpha 1

PSMA1

5

3

Transporters

   

   syntaxin 4

STX4

3

2

Others

   

   trans-golgi network protein 2

TGOLN2

113

106

   LIM and senescent cell antigen-like domains 1

LIMS1

94

75

   fibrinogen gamma chain

FGG

94

3

   collagen, type XII, alpha 1

COL12A1

26

28

   extracellular proteinase inhibitor

EXPI

3

3

  1. Gene description names, gene symbols are from IPA Tool