Figure 13
From: Comparing 2-nt 3' overhangs against blunt-ended siRNAs: a systems biology based study
2-nt 3' and blunt-ended siRNAs with RDR. Figure 13 shows the effects of high amplification through RDR and we can observe sustained gene silencing. The actual mRNA levels will however depend on the amplification rates and initial number of dsRNA molecules inserted into the cell.