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Table 4 Cholesterol biosynthesis pathway. This table lists the proteins that are the constituents of the cholesterol biosynthesis pathway (Figure 5E). Column 1 gives the uniprot identifier, column 2 the short gene description, column 3 the gene symbol and column 4 highlights the features of this protein, including whether or not it is a HIV-1, siRNA or drug target.

From: Alternative paths in HIV-1 targeted human signal transduction pathways

Uniprot id Gene description Gene Symbol Properties
Q01581 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble) HMGCS1 siRNA protein
Q03426 mevalonate kinase MVK None
Q14534 squalene epoxidase SQLE Known drug target
P48449 lanosterol synthase (2 3-oxidosqualene-lanosterol cyclase) LSS Known drug target
Q15126 phosphomevalonate kinase PMVK None
P53602 mevalonate (diphospho) decarboxylase MVD None
O95749 geranylgeranyl diphosphate synthase 1 GGPS1 None
P37268 farnesyl-diphosphate farnesyltransferase 1 FDFT1 HIV-1 target according to predictions