Figure 3

Characteristics of rate-limiting enzymes in inhibitory network. (a) Color-grid for the role of rate-limiting enzymes in the inhibitory network as inhibiting initiators and targets. (b) Inhibitory efficiencies of rate-limiting enzymes as inhibitor initiators in inhibitory networks pairwise among six pathway groups. For each cell, the ratio represents the inhibited enzymes in the column pathway group by the products of rate-limiting enzymes from the row pathway group to the inhibited enzymes in the column pathway by the products of all metabolic enzymes from the row pathway group. The pathway names on left are: C_V (metabolism of cofactors and vitamins), AA (amino acid metabolism), C (carbohydrate metabolism), N (nucleotide metabolism), L (lipid metabolism) and O (other metabolism pathways).