Genomics based analysis of interactions between developing B-lymphocytes and stromal cells reveal complex interactions and two-way communication

Table 4 Analysis of communication pathways for Common Lymphoid Progenitors (CLP)

Gene expressed in CLP	Mean Intensity	Corresponding gene in stroma	Mean Intensity	NIH3T3	Osteoblasts
interleukin 2 receptor, gamma chain	3021	interleukin 7	189	92	255
chemokine (C-X-C motif) receptor 4	2121	chemokine (C-X-C motif) ligand 12	12222	23	798
integrin alpha 4	1982	vascular cell adhesion molecule 1	692	182	929
integrin alpha 4	1982	junction adhesion molecule 2	201	16	26
integrin beta 2	920	junction adhesion molecule 3	152	42	204
Bone morphogenetic protein 15	645	bone morphogenetic protein receptor, type 1A	497	274	384
chemokine (C-C motif) receptor 9	443	chemokine (C-C motif) ligand 25	123	55	100
insulin-like growth factor 2	282	insulin-like growth factor 2 receptor	535	1772	1704
epidermal growth factor receptor	193	epiregulin	422	288	153
epidermal growth factor receptor	193	transforming growth factor alpha	261	13	21
interleukin 1 receptor, type I	180	interleukin 1 receptor antagonist	3515	16	10
activin receptor IIB	166	bone morphogenetic protein 4	1335	66	252
interleukin 1 receptor, type II	127	interleukin 1 receptor antagonist	3515	16	10
oncostatin M	112	oncostatin M receptor	1151	1349	131

ISSN: 1471-2164