From: Functional annotation of novel lineage-specific genes using co-expression and promoter analysis
Cluster | aTFBS singles and pairs | P-value | P-valuec | Ref. | CRSD pathway (<10-03) and PREMOD identifierd |
---|---|---|---|---|---|
LIVR | Oct-1b | 0.002 | 0.152 | [37] | NAe |
 | p53 | 0.002 | 0.152 | [36] | NA |
 | Sp1*Pax-8 | 0.001 | 0.049 | [72] | Agrin in postsynaptic differentiation; glycerophospholipid metabolism |
 | SREBP-1*Pax-8b | 0.002 | 0.049 | [40] | glycerophospholipid metabolism; Agrin in postsynaptic differentiation |
 | ZF5*YY1 | 0.002 | 0.049 | [73] | Wnt signaling pathway; antisense pathway |
 | Ebox*c-Ets-1(p54) | 0.004 | 0.052 | [74] | nicotinate and nicotinamide metabolism; signal transduction |
 | AP-2, ZF5, c-Ets -1(p54)b | 0.027 | 0.026 | [43] | adipocytokine signaling pathway; HIV-I Nef: negative effector of Fas and TNF |
PLAC | STAT*Pax-2b | 0.0009 | 0.10 | glycerolipid metabolism (with STAT family); prion pathway; mod027529 | |
 | Tax/CREB*ETF | 10-05 | 0.039 | NA | EGFR-specific transcription factor (ETF) not found in CRSD |
 | Oct-1*GATA-4 | 0.0009 | 0.10 | [77] | mod003360; mod065501; mod070287 |
 | Tel-2*VDR | 0.0005 | 0.10 | NA | Phosphatidylinositol signaling system; mod100969 |
THYM | v-Mybb | 10-05 | 0.069 | [78] | NA |
 | KROX | 0.004 | 0.224 | [79] | NA |
 | Nkx2-5*CdxAb | 0.0006 | 0.077 | [54] | N-glycan biosynthesis; ribosome; mod004754 |
 | MAF*HOXA7 | 0.0002 | 0.077 | NA | phospholipase C-epsilon pathway |