Table 2 Presence of genes related to colonization, persistence or pathogenesis in the H. mustelae genome, compared to H. pylori
Trait | H. pylori locus | Orthologous H. mustelae system | Comments |
|---|---|---|---|
Cag pathogenicity | cag PAI | absent | Cag PAI linked to severity of pathology and disease |
Urease production | Urease operon (ure) | UreAB and UreAB2 loci (HMU03050-030110) and HMU13010-13020) | Contributes to acid resistance |
Vacuolating cytotoxin | vacA | absent | Cytotoxicity including T-cell inhibition |
Autotransporters | VacA and paralogs | 10 genes including Hsr locus (Fig. S1) | Two proteins with low identity to VacA; others - function unknown |
Outer membrane adhesins | Hop, Hor, Hof, Hom paralogue families | No orthologs of BabA, SabA, OipA or AlpA/B. | Three OMPs related to Hof family; function unknown; three Hor-Hom homolgues |
Invasion antigen | None | CiaB HMU0700 | C. jejuni homolog enhances cell invasion |
Neutrophil activation | NapA | HMU1269 | Activates neutrophils & contributes oxidative stress resistance |
HpaA | HP0797 | absent | Putative adhesin and flagellum sheath lipoprotein |
Motility | Fla/Flg/Fli/Flh | Fla/Flg/Fli/Flh | Motility is required for gastric colonization |
Collagenase secretion | HP0169 | HMU02630 | Required for H. pylori colonization of Mongolian gerbil |
Adhesion/tissue damage | - | HMU00160-HMU00170 Hag/Hly | Putative haemagglutinin/haemolysin |
Plasminogen binding | HP0508 | HMU02820; HMU09010 | Could enhance tissue damage by proteolysis |