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Table 2 Presence of genes related to colonization, persistence or pathogenesis in the H. mustelae genome, compared to H. pylori

From: Comparative genomics and proteomics of Helicobacter mustelae, an ulcerogenic and carcinogenic gastric pathogen

Trait H. pylori locus Orthologous H. mustelae system Comments
Cag pathogenicity cag PAI absent Cag PAI linked to severity of pathology and disease
Urease production Urease operon (ure) UreAB and UreAB2 loci (HMU03050-030110) and HMU13010-13020) Contributes to acid resistance
Vacuolating cytotoxin vacA absent Cytotoxicity including T-cell inhibition
Autotransporters VacA and paralogs 10 genes including Hsr locus (Fig. S1) Two proteins with low identity to VacA; others - function unknown
Outer membrane adhesins Hop, Hor, Hof, Hom paralogue families No orthologs of BabA, SabA, OipA or AlpA/B. Three OMPs related to Hof family; function unknown; three Hor-Hom homolgues
Invasion antigen None CiaB HMU0700 C. jejuni homolog enhances cell invasion
Neutrophil activation NapA HMU1269 Activates neutrophils & contributes oxidative stress resistance
HpaA HP0797 absent Putative adhesin and flagellum sheath lipoprotein
Motility Fla/Flg/Fli/Flh Fla/Flg/Fli/Flh Motility is required for gastric colonization
Collagenase secretion HP0169 HMU02630 Required for H. pylori colonization of Mongolian gerbil
Adhesion/tissue damage - HMU00160-HMU00170 Hag/Hly Putative haemagglutinin/haemolysin
Plasminogen binding HP0508 HMU02820; HMU09010 Could enhance tissue damage by proteolysis