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Table 2 Top-ranked differentially expressed genes in Coriell-18, ECACC-6 and Nf1-Mouse-12 sample sets.

From: Evidence of perturbations of cell cycle and DNA repair pathways as a consequence of human and murine NF1-haploinsufficiency

Coriell-18

P value

FDR

FD

Gene

1

0.0001

0.162

0.57

IFI6

2

0.0001

0.162

0.78

CNKSR3

3

0.0001

0.162

1.23

AKAP2

4

0.0001

0.162

0.67

OAS1

5

0.0001

0.162

1.27

ZRANB1

6

0.0001

0.162

0.66

TCN2

7

0.0001

0.164

0.72

GAS2

8

0.0002

0.164

0.64

OAS3

9

0.0002

0.164

0.66

HERC5

10

0.0002

0.164

0.69

EPSTI1

11

0.0002

0.164

0.81

NDUFC1

12

0.0002

0.164

0.80

ACOT9

13

0.0002

0.164

0.74

RFC5

14

0.0003

0.164

0.86

NMI

15

0.0003

0.170

1.26

DYRK2

16

0.0003

0.193

0.75

LGP2

17

0.0006

0.272

1.12

LRRC37B

18

0.0006

0.272

0.80

PPP2R4

ECACC-6

P value

FDR

FD

Gene

1

0.8 × 10-6

0.008

2.65

HMHB1

2

0.8 × 10-5

0.038

2.96

HAVCR2

3

0.2 × 10-4

0.067

1.80

CHURC1

4

0.0001

0.232

1.76

GIMAP5

5

0.0003

0.473

1.69

GIMAP6

6

0.0003

0.473

1.34

RORA

7

0.0004

0.473

0.58

ADM

8

0.0004

0.473

0.66

DNAJC15

9

0.0005

0.473

0.54

C3orf59

10

0.0005

0.473

1.45

RAB31

11

0.0006

0.553

1.65

PSTPIP2

12

0.0007

0.553

1.33

PACSIN2

13

0.0008

0.554

1.35

MYB

14

0.0009

0.554

0.75

ISCU

15

0.0009

0.554

1.36

PKHD1L1

16

0.0009

0.554

0.69

ASB2

17

0.0010

0.575

0.74

DUSP14

18

0.0011

0.575

0.75

IMPA1

Nf1 -Mouse-12

P value

FDR

FD

Gene

1

0.1 × 10-6

0.001

1.42

2010305C02Rik

2

0.2 × 10-5

0.011

1.29

C730049P21

3

0.3 × 10-5

0.014

1.30

Inpp5k

4

0.0003

0.879

1.23

H2-T10

5

0.0004

0.879

1.29

Pnkd

6

0.0004

0.879

1.42

Cxcr3

7

0.0005

0.903

1.24

Gsg2

8

0.0009

1.000

1.27

Gstt3

9

0.0009

1.000

1.38

9130213B05Rik

10

0.0009

1.000

1.19

Igtp

11

0.0010

1.000

1.18

Rnf43

12

0.0010

1.000

1.50

Serpina3f

13

0.0011

1.000

1.17

Ncapd2

14

0.0013

1.000

1.19

Inpp5k

15

0.0014

1.000

1.17

Slc25a19

16

0.0015

1.000

1.40

LOC238447

17

0.0020

1.000

0.87

Gosr1

18

0.0021

1.000

1.24

LOC327957

  1. To evaluate statistical significance of the differential expression of genes, t tests were performed for two human and the mouse sample sets. In each list, genes were ranked according to their False Discovery Rate (FDR). Significant genes with FDR< 0.25 are shown in boldface. "FD" - Fold Difference of expression values of NF1-affecteds vs. NF1-unaffecteds, or Nf1+/- vs. wild-type mice.