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Table 2 Top-ranked differentially expressed genes in Coriell-18, ECACC-6 and Nf1-Mouse-12 sample sets.

From: Evidence of perturbations of cell cycle and DNA repair pathways as a consequence of human and murine NF1-haploinsufficiency

Coriell-18 P value FDR FD Gene
1 0.0001 0.162 0.57 IFI6
2 0.0001 0.162 0.78 CNKSR3
3 0.0001 0.162 1.23 AKAP2
4 0.0001 0.162 0.67 OAS1
5 0.0001 0.162 1.27 ZRANB1
6 0.0001 0.162 0.66 TCN2
7 0.0001 0.164 0.72 GAS2
8 0.0002 0.164 0.64 OAS3
9 0.0002 0.164 0.66 HERC5
10 0.0002 0.164 0.69 EPSTI1
11 0.0002 0.164 0.81 NDUFC1
12 0.0002 0.164 0.80 ACOT9
13 0.0002 0.164 0.74 RFC5
14 0.0003 0.164 0.86 NMI
15 0.0003 0.170 1.26 DYRK2
16 0.0003 0.193 0.75 LGP2
17 0.0006 0.272 1.12 LRRC37B
18 0.0006 0.272 0.80 PPP2R4
ECACC-6 P value FDR FD Gene
1 0.8 × 10-6 0.008 2.65 HMHB1
2 0.8 × 10-5 0.038 2.96 HAVCR2
3 0.2 × 10-4 0.067 1.80 CHURC1
4 0.0001 0.232 1.76 GIMAP5
5 0.0003 0.473 1.69 GIMAP6
6 0.0003 0.473 1.34 RORA
7 0.0004 0.473 0.58 ADM
8 0.0004 0.473 0.66 DNAJC15
9 0.0005 0.473 0.54 C3orf59
10 0.0005 0.473 1.45 RAB31
11 0.0006 0.553 1.65 PSTPIP2
12 0.0007 0.553 1.33 PACSIN2
13 0.0008 0.554 1.35 MYB
14 0.0009 0.554 0.75 ISCU
15 0.0009 0.554 1.36 PKHD1L1
16 0.0009 0.554 0.69 ASB2
17 0.0010 0.575 0.74 DUSP14
18 0.0011 0.575 0.75 IMPA1
Nf1 -Mouse-12 P value FDR FD Gene
1 0.1 × 10-6 0.001 1.42 2010305C02Rik
2 0.2 × 10-5 0.011 1.29 C730049P21
3 0.3 × 10-5 0.014 1.30 Inpp5k
4 0.0003 0.879 1.23 H2-T10
5 0.0004 0.879 1.29 Pnkd
6 0.0004 0.879 1.42 Cxcr3
7 0.0005 0.903 1.24 Gsg2
8 0.0009 1.000 1.27 Gstt3
9 0.0009 1.000 1.38 9130213B05Rik
10 0.0009 1.000 1.19 Igtp
11 0.0010 1.000 1.18 Rnf43
12 0.0010 1.000 1.50 Serpina3f
13 0.0011 1.000 1.17 Ncapd2
14 0.0013 1.000 1.19 Inpp5k
15 0.0014 1.000 1.17 Slc25a19
16 0.0015 1.000 1.40 LOC238447
17 0.0020 1.000 0.87 Gosr1
18 0.0021 1.000 1.24 LOC327957
  1. To evaluate statistical significance of the differential expression of genes, t tests were performed for two human and the mouse sample sets. In each list, genes were ranked according to their False Discovery Rate (FDR). Significant genes with FDR< 0.25 are shown in boldface. "FD" - Fold Difference of expression values of NF1-affecteds vs. NF1-unaffecteds, or Nf1+/- vs. wild-type mice.