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Figure 4 | BMC Genomics

Figure 4

From: Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes

Figure 4

Effects of Tyk2 and LPS on genes with IRF/ISRE TFBS. Effects of (A) Tyk2 genotype (Wt minus Tyk2-/-), (B) LPS treatment (6 hours of LPS minus control), and (C) genotype by treatment interaction (difference in LPS induction between Wt and Tyk2-/-) on expression levels of genes containing the IRF/ISRE TFBS, plotted as NCs (y-axis) against relative ranks (absolute rank divided by the number of genes; x-axis). Thick solid lines represent NCs; thin solid lines the values of all genes (see Figure 1) in order to highlight the effects on genes with IRF/ISRE TFBS relative to all genes analyzed.

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BMC Genomics

ISSN: 1471-2164

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