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Table 6 Differentially regulated genes involved in cellular energy production at 3 months

From: Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGFδ/δ mouse model of amyotrophic lateral sclerosis

Probe ID

Gene title

Symbol

p value

FC

Regn

Electron transport chain

1438159

NADH dehydrogenase (ubiquinone) flavoprotein 2

Ndufv2

0.0330

1.15

up

1435757

Ubiquinol cytochrome C reductase core protein 2

Uqcrc2

0.0066

1.21

up

1456588

Cytochrome c oxidase, subunit Vb

Cox5b

0.0460

1.16

up

1450561

Surfeit gene 1

Surf1

0.0187

1.16

up

1449710

ATP synthase H+ transporting, mitochondrial F1 complex, α subunit, isoform 1

Atp5a1

0.0216

1.09

up

1454661

ATP synthase H+ transporting, mitochondrial F0 complex, subunit c, isoform 3

Atp5g3

0.0309

1.06

up

1418127

Programmed cell death 8 (Apoptosis inducing factor)

Pcdc8

0.0185

1.26

up

TCA cycle

1419737

Lactate dehydrogenase 1, A chain

Ldh1

0.0077

1.86

down

1433984

Malate dehydrogenase 2, NAD

Mdh2

0.0188

1.16

up

1455235

Lactate dehydrogenase 2, B chain

Ldh2

0.0216

1.12

up

1436750

3-oxoacid CoA transferase1

Oxct1

0.0441

1.30

up

Free radical scavenging

1430979

Peroxiredoxin 2

Prdx2

0.0397

1.27

up

1444531

Superoxide dismutase 2, mitochondrial

Sod2

0.0417

1.20

up