Skip to main content

Table 1 Gene Set Enrichment Analysis (GSEA) of liver transcriptome of HgCl2-treated zebrafish.

From: Mercury-induced hepatotoxicity in zebrafish: in vivo mechanistic insights from transcriptome analysis, phenotype anchoring and targeted gene expression validation

  Up-regulated NES Down-regulated NES
8 h    Electron transport chain -2.1201 (15)
    Mitochondrial fatty acid beta-oxidation -1.4134 (10)
    Nuclear receptor signaling pathway -1.484 (7)
    Extrinsic apoptotic pathway -1.5717 (4)
24 h Proteasome pathway 1.7531 (7) Mitochondrial fatty acid beta-oxidation -1.7489 (10)
  Complement activation (classical) 1.6751 (2)   
48 h Proteasome pathway 2.0369 (8) Mitochondrial fatty acid beta-oxidation -1.5011 (6)
  Electron transport chain 1.6143 (15) Nuclear receptor signaling pathway -1.689 (8)
96 h Proteasome pathway 1.9855 (5) Non-substrate GSK3 interacting proteins -1.533 (5)
  Complement activation (classical) 1.435 (2) Cell cycle -1.3784 (12)
  DNA damage signaling pathway 1.4009 (14) Wnt signaling pathway -1.337 (8)
  Actin pathway 1.7501 (3)   
  Fatty acid synthesis 1.5715 (4)   
  Intrinsic apoptotic pathway 1.401 (4)   
  Hypoxia-induced factor pathway 1.3243 (5)   
  Cell motility 1.2936 (5)   
  Gluconeogenesis 1.0784 (7)   
  Electron transport chain 1.6832 (18)   
  1. Biological pathways that are statistically enriched with false discovery rate (FDR) < 0.3 or nominal p-value (NP) < 0.1 are shown. Values of normalized enrichment score (NES) indicate the activities of enriched pathways with positive and negative NES shows up- and down-regulation, respectively. Number of leading edge genes for each pathway is given in bracket besides the NES values.