Table 1 Gene Set Enrichment Analysis (GSEA) of liver transcriptome of HgCl2-treated zebrafish.
| Â | Up-regulated | NES | Down-regulated | NES |
|---|---|---|---|---|
8 h | Â | Â | Electron transport chain | -2.1201 (15) |
| Â | Â | Â | Mitochondrial fatty acid beta-oxidation | -1.4134 (10) |
| Â | Â | Â | Nuclear receptor signaling pathway | -1.484 (7) |
| Â | Â | Â | Extrinsic apoptotic pathway | -1.5717 (4) |
24 h | Proteasome pathway | 1.7531 (7) | Mitochondrial fatty acid beta-oxidation | -1.7489 (10) |
| Â | Complement activation (classical) | 1.6751 (2) | Â | Â |
48 h | Proteasome pathway | 2.0369 (8) | Mitochondrial fatty acid beta-oxidation | -1.5011 (6) |
| Â | Electron transport chain | 1.6143 (15) | Nuclear receptor signaling pathway | -1.689 (8) |
96 h | Proteasome pathway | 1.9855 (5) | Non-substrate GSK3 interacting proteins | -1.533 (5) |
| Â | Complement activation (classical) | 1.435 (2) | Cell cycle | -1.3784 (12) |
| Â | DNA damage signaling pathway | 1.4009 (14) | Wnt signaling pathway | -1.337 (8) |
| Â | Actin pathway | 1.7501 (3) | Â | Â |
| Â | Fatty acid synthesis | 1.5715 (4) | Â | Â |
| Â | Intrinsic apoptotic pathway | 1.401 (4) | Â | Â |
| Â | Hypoxia-induced factor pathway | 1.3243 (5) | Â | Â |
| Â | Cell motility | 1.2936 (5) | Â | Â |
| Â | Gluconeogenesis | 1.0784 (7) | Â | Â |
| Â | Electron transport chain | 1.6832 (18) | Â | Â |