Mercury-induced hepatotoxicity in zebrafish: in vivo mechanistic insights from transcriptome analysis, phenotype anchoring and targeted gene expression validation

Table 2 Gene Set Enrichment Analysis (GSEA) of transcriptome of mercury-treated human HepG2 cells.

Enriched processes	NES HepG2
Cell cycle	2.2425
Pyrimidine metabolism	2.049
DNA repair	1.6355
DNA damage signaling*	1.4957
Proteasome pathway*	1.5095
Electron transport chain*	-1.4248
Nuclear receptor signaling pathway*	-1.5093
Mitochondrial fatty acid beta-oxidation*	-1.7171

Biological pathways that are statistically enriched with false discovery rate (FDR) < 0.3 or nominal p-value (NP) < 0.1 are considered. * indicate pathways that are common in zebrafish and HepG2 cell treated with HgCl₂.

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