Figure 1
From: Acetylation of p65 at lysine 314 is important for late NF-κB-dependent gene expression
Site-specific acetylation of p65 regulates the expression of distinct genes. Heat maps showing the gene expression profiles of KTR cells (A) or K314/315R cells (B) compared to wild type control at 3 hours after TNFα stimulation using whole mouse genome arrays. Each row represents a single gene, and each column represents a different cell line. Red or green represents up- or downregulation of genes relative to the mean on each row, respectively. Mean data from at least two biological replicates is displayed. Only genes upregulated in wild type cells compared to pTV control were taken into account (>2-fold, p-value < 0.05). From these genes, only the ones with significant changes in expression levels (> 1.8-fold or < 0.556-fold, p-value < 0.05) between wild type and mutant cells are shown.