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Table 2 Regulatory signal transduction pathways and corresponding gene members found differentially expressed during epileptogenesis.

From: Whole transcriptome analysis of the hippocampus: toward a molecular portrait of epileptogenesis

Signaling Pathway D3 vs. CTRL D7 vs. CTRL CHRONIC vs. CTRL D3, D7 and CHRONIC vs. CTRL
  Up-regulated Down-regulated Up-regulated Down-regulated Up-regulated Down-regulated Up-regulated Down-regulated
MAPK Tgfbr1, Acvr1c Prkcc Tgfb1 - P38 Mapk, Fgf7, Rasa2 Map2k1 Cacna1g, Casp4, Gadd45a -
Wnt Plcb2 Prkcc - - - - - -
Notch - Hes5 - - - - - -
TGF-beta Tgfbr1, Tgfb1, Acvr1c - Tgfb1 - Tgfb1 - Tgfb1 -
Jak-STAT Stat3, Jak3 - Pik3r1, Ifngr1 - Pik3r3 - Csf2rb1 -
Calcium Plcb2 Prkcc, Cckbr - - - - Cacna1g -
Phosphatidyl Inositol Plcb2 Prkcc Pik3r1 - Pik3r3 - Pik3c2b -
mTOR Igf1   Igf1   Igf1   Igf1  
  1. *D3 = three days post-SE; D7 = seven days post-SE; Chronic = immediately after the first spontaneous seizure; CTRL = saline-treated, time-matched control.