Table 2 Regulatory signal transduction pathways and corresponding gene members found differentially expressed during epileptogenesis.
From: Whole transcriptome analysis of the hippocampus: toward a molecular portrait of epileptogenesis
Signaling Pathway | D3 vs. CTRL | D7 vs. CTRL | CHRONIC vs. CTRL | D3, D7 and CHRONIC vs. CTRL | ||||
|---|---|---|---|---|---|---|---|---|
Up-regulated | Down-regulated | Up-regulated | Down-regulated | Up-regulated | Down-regulated | Up-regulated | Down-regulated | |
MAPK | Tgfbr1, Acvr1c | Prkcc | Tgfb1 | - | P38 Mapk, Fgf7, Rasa2 | Map2k1 | Cacna1g, Casp4, Gadd45a | - |
Wnt | Plcb2 | Prkcc | - | - | - | - | - | - |
Notch | - | Hes5 | - | - | - | - | - | - |
TGF-beta | Tgfbr1, Tgfb1, Acvr1c | - | Tgfb1 | - | Tgfb1 | - | Tgfb1 | - |
Jak-STAT | Stat3, Jak3 | - | Pik3r1, Ifngr1 | - | Pik3r3 | - | Csf2rb1 | - |
Calcium | Plcb2 | Prkcc, Cckbr | - | - | - | - | Cacna1g | - |
Phosphatidyl Inositol | Plcb2 | Prkcc | Pik3r1 | - | Pik3r3 | - | Pik3c2b | - |
mTOR | Igf1 | Igf1 | Igf1 | Igf1 | ||||