Pathological examination of liver in mice model with fulminant hepatitis induced by ConA-injection. ConA induced fulminant hepatitis was confirmed by using pathological examination. Mice liver tissue was obtained at indicated time periods and stained with haematoxylin and eosin. ConA caused pathological changes in mice liver after ConA challenge from the photomicrographs presented. Necrosis appeared at 12 h after ConA administration and the severity of necrosis increased with the time. A large area of necrosis was found at 72 h after ConA injection.