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Table 1 Candidate kinases that phosphorylate 12E8 tau

From: High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation

  

12E8 Tau/Control

Total Tau

12E8 Tau/Total Tau

Gene Name

Cell Count

Average

St Dev

p value

Average

St Dev

p value

Average

St Dev

p value

MARK2

453

0.672

0.044

0.006

0.979

0.039

0.451

0.687

0.060

0.012

PAK3

170

0.803

0.067

0.036

1.112

0.197

0.429

0.730

0.072

0.023

PAK2

287

0.726

0.081

0.028

0.986

0.101

0.831

0.741

0.109

0.054

ADCK5

280

0.716

0.104

0.042

0.934

0.094

0.351

0.765

0.069

0.028

AKAP13

181

0.738

0.069

0.023

0.929

0.070

0.223

0.797

0.086

0.054

LOC55971

152

0.836

0.035

0.014

0.982

0.019

0.241

0.852

0.042

0.026

PLK2

335

0.774

0.087

0.046

0.906

0.114

0.289

0.856

0.052

0.040

DYRK1A

316

0.774

0.051

0.017

0.848

0.104

0.127

0.860

0.038

0.023

MAK

393

1.109

0.021

0.012

0.919

0.037

0.063

1.209

0.054

0.021

ITK

285

1.124

0.036

0.027

0.887

0.059

0.079

1.273

0.118

0.057

PIM1

409

1.248

0.097

0.047

0.965

0.105

0.624

1.297

0.080

0.023

RAGE

397

1.305

0.106

0.038

0.960

0.088

0.511

1.361

0.053

0.007

ITPK1

399

1.324

0.119

0.042

0.930

0.084

0.285

1.424

0.024

0.001

CKB

223

1.537

0.143

0.023

1.065

0.146

0.523

1.454

0.138

0.030

PFKM

375

1.305

0.096

0.032

0.888

0.112

0.227

1.476

0.082

0.010

DGKB

440

1.350

0.096

0.024

0.921

0.163

0.488

1.489

0.200

0.052

SPHK2

333

1.792

0.282

0.040

1.074

0.121

0.399

1.664

0.114

0.010

  1. A list of kinases affecting 12E8 tau phosphorylation. Shown are the most significant effectors of 12E8 tau phosphoylration emerging from a high-content siRNA screen of the complete "kinome." Indicated in the columns from left to right are, the Gene Name, the cell counts (which refers to the number of cells in the well following transfection and is and indicator of potential siRNA toxicity), and then the average fold effect, standard deviation, and p value for 12E8 tau, total tau, and the ratio of 12E8 tau/total tau. For a reference on cell counts, non-siliencing s iRNA control cell counts range from ~330-380, depending on the individual plates in the assay. This tabel contains only those siRNAs that affect pS262 tau/total tau through significant effects on pS262 tau alone. Total tau levels were selected to be insignificantly effected (p > 0.05), although some candidates clearly show a strong trend toward significant reductions in total tau.
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BMC Genomics

ISSN: 1471-2164

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