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Table 2 Candidate kinases affecting total tau and 12E8 tau expression

From: High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation

  

12EB Tau/Control

Total Tau

12E8 Tau/Total Tau

Gene Name

Cell Count

Average

St Dev

p value

Average

St Dev

p value

Average

St Dev

p value

EIF2AK2

217

0.606

0.075

0.012

0.647

0.102

0.026

0.962

0.237

0.806

EIF2AK2

318

0.719

0.069

0.018

0.706

0.082

0.025

1.038

0.257

0.822

CDKL1

398

0.852

0.032

0.015

0.761

0.085

0.040

1.132

0.157

0.281

DCK

363

1.068

0.015

0.017

0.701

0.051

0.010

1.530

0.107

0.013

DGKQ

406

1.119

0.042

0.039

0.805

0.059

0.029

1.394

0.111

0.026

PFKFB3

458

1.204

0.046

0.016

0.813

0.029

0.008

1.483

0.088

0.011

ERK8

466

1.234

0.063

0.024

0.807

0.009

0.001

1.528

0.084

0.008

STK19

347

1.334

0.103

0.030

0.654

0.115

0.035

2.065

0.231

0.015

PRKG2

413

1.384

0.152

0.048

0.721

0.107

0.046

1.959

0.412

0.056

MAP2K1IP1

436

1.393

0.052

0.006

0.831

0.048

0.026

1.679

0.123

0.011

  1. Kinases that affect bioth 12E8 tau and total tau levels. Shown are those kinases that affect total tau levels and 12E8 tau levels, irrespective of significant effects to the ratio of 12E8 tau/total tau. Columns are labeled as in Table 1.
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BMC Genomics

ISSN: 1471-2164

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