Table 2 List of top 5 networks, canonical pathways and molecular functional pathways, for gene differentially regulated by tPA in the reperfused-MCAO group and permanent-MCAO group (p ≤ 0.01, fold change ≥ |1.2|).
From: Genome response to tissue plasminogen activator in experimental ischemic stroke
Reperfused-MCAO | Permanent-MCAO | |||||
|---|---|---|---|---|---|---|
Network | IPA Score | Network | IPA Score | |||
1 | Carbohydrate Metabolism, Lipid Metabolism, Small Molecule Biochemistry | 43 | Gene Expression, Cell Cycle, Lipid Metabolism | 41 | ||
2 | Organismal Survival, Connective Tissue Development and Function, Tissue Development | 43 | Cellular Assembly and Organization, Cellular Function and Maintenance, Cancer | 34 | ||
3 | Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry | 39 | Genetic Disorder, Metabolic Disease, Neurological Disease | 25 | ||
4 | Inflammatory Response, Connective Tissue Disorders, Inflammatory Disease | 34 | Cellular Compromise, Drug Metabolism, Endocrine System Development and Function | 25 | ||
5 | Cellular Compromise, Cell Morphology, Endocrine System Development and Function | 22 | DNA Replication, Recombination, and Repair, Cancer, Cell Cycle | 22 | ||
Canonical Pathway | P-value | Canonical Pathway | P-value | |||
1 | Nicotinate and Nicotinamide Metabolism | 3.27E-04 | FcgRIIB Signaling in B Lymphocytes | 1.01E-02 | ||
2 | Hypoxia Signaling in the Cardiovascular System | 8.48E-04 | p38 MAPK Signaling | 1.89E-02 | ||
3 | Role of NFAT in Regulation of the Immune Response | 4.77E-03 | Glucocorticoid Receptor Signaling | 2.33E-02 | ||
4 | B Cell Receptor Signaling | 1.72E-02 | Estrogen Receptor Signaling | 3.09E-02 | ||
5 | TREM1 Signaling | 1.97E-02 | Macropinocytosis | 3.86E-02 | ||
Molecular Functional Pathway | P-value | Molecular Functional Pathway | P-value | |||
1 | Cell-To-Cell Signaling and Interaction | 7.10E-04 - 4.50E-02 | Gene Expression | 1.65E-04 - 1.29E-02 | ||
2 | Cellular Assembly and Organization | 7.10E-04 - 3.47E-02 | Cell-To-Cell Signaling and Interaction | 6.52E-04 - 4.37E-02 | ||
3 | Cell Cycle | 1.40E-03 - 3.93E-02 | Cellular Movement | 8.51E-04 - 4.56E-02 | ||
4 | Cellular Function and Maintenance | 1.97E-03 - 3.33E-02 | Carbohydrate Metabolism | 1.61E-03 - 3.81E-02 | ||
5 | Cell death/Survival | 2.09E-03 - 2.85E-02 | Cellular Assembly and Organization | 2.03E-03 - 4.69E-02 | ||