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Table 2 Known dioxin-inducible genes

From: Aryl hydrocarbon receptor (AHR)-regulated transcriptomic changes in rats sensitive or resistant to major dioxin toxicities

Resistant Collective Sensitive Collective    
H/W LnA L-E LnC    
FC log2 padj FC log2 padj FC log2 padj FC log2 padj Gene ID Symbol Full Name
6.3 3.2 × 10-9 5.4 8.2 × 10-8 6.8 2.2 × 10-12 6.2 8.9 × 10-10 25375 Aldh3a1 aldehyde dehydrogenase 3 family, member A1
6.4 1.3 × 10-4 6.1 1.0 × 10-6 6.6 3.3 × 10-8 6.4 1.8 × 10-9 24296 Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1
1.2 2.0 × 10-5 1.2 1.6 × 10-5 1.1 1.5 × 10-6 1.1 1.9 × 10-5 24297 Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2
3.9 6.8 × 10-5 3.5 4.9 × 10-7 5.3 4.4 × 10-6 4.9 7.8 × 10-6 25426 Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1
1.2 4.4 × 10-3 1.1 1.9 × 10-3 1.9 3.8 × 10-4 1.4 1.9 × 10-3 83619 Nfe2l2 nuclear factor, erythroid derived 2, like 2
3.7 3.2 × 10-5 2.5 1.4 × 10-4 2.4 4.9 × 10-5 2.6 4.5 × 10-5 24314 Nqo1 NAD(P)H dehydrogenase, quinone 1
2.3 1.2 × 10-3 1.8 1.3 × 10-3 2.5 1.6 × 10-4 2.2 1.7 × 10-4 310467 Tiparp TCDD-inducible poly(ADP-ribose) polymerase
  1. Transcriptional responses after 19-hour TCDD exposure in the four rat strains/lines were identified using Affymetrix RAE230A arrays followed by data pre-processing and statistical testing using linear models. Twenty-five Type-I genes (similar response to TCDD in all four strains/lines) were identified. These included several well-established AHR-regulated and dioxin-inducible genes, supporting the validity of the array experiments. For each strain/line, the fold-change (FC in log2 space) in mRNA levels between treated and control rats as well as the significance levels are presented.