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Table 5 Functions of the biologically relevant genes found in prostate cancer.

From: Novel methods to identify biologically relevant genes for leukemia and prostate cancer from gene expression profiles

Gene Name Gene Function Evidence References
HPN Plays an essential role in cell growth and maintenance of cell morphology. [59]
S100A4 S100 calcium binding protein A4. [52]
RBP1 Intracellular transport of retinol. [25]
ANGPT1 Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. [50]
COL4A6 Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans, and entactin/nidogen. [53]
NELL2 Chicken nel-like 2 homolog with a wide and weak expression, expressed in adult and fetal brain and hemopoietic cells (nucleated peripheral blood cells) but not in B cells. [48]
GSTM1 Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. [49]
PTGDS It is likely to play important roles in both maturation and maintenance of the central nervous system and male reproductive system. [54]
TARP Transmembrane receptor activity. [58]
LMO3 Lim domain only 3. [56]
DIO2 Essential for providing the brain with appropriate levels of T3 (3,5,3'-triiodothyronine) during the critical period of development. [57]
SERBP1 May play a role in the regulation of mRNA stability. [55]
TNFSF10 Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. [51]