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Table 4 LPS and PMA/ionomycin stimulation: top biological functions from the catalogs Diseases and Disorders1, Molecular and Cellular Functions2 and Physiological System Development and Function3 identified by IPA and number of focus genes

From: Transcriptome analysis of porcine PBMCs after in vitro stimulation by LPS or PMA/ionomycin using an expression array targeting the pig immune response

Stimulation Top biological functions # genes4 Fisher p-value
LPS Cellular Growth and Proliferation2 126/2404 2.25E-18 - 7.17E-07
  Cell Death2 114/2259 2.00E-27 - 9.59E-07
  Immunological Disease1 113/1730 3.40E-46 - 9.59E-07
  Immune Response3 113/475 6.00E-23 - 9.56E-07
  Inflammatory Disease1 108/401 2.58E-45 - 1.06E-06
  Hematological System Development and Function3 101/1446 6.70E-28 - 8.53E-07
  Cell-To-Cell Signaling and Interaction2 99/1465 2.44E-24 - 4.29E-07
  Cellular Movement2 92/1364 6.70E-28 - 8.33E-07
  Immune and Lymphatic System Development and Function3 92/430 3.43E-19 - 8.03E-07
  Skeletal and Muscular Disorders1 83/2024 2.52E-39 - -2.26E-07
  Cellular Development2 82/1899 1.66E-15 - 1.08E-06
  Connective Tissue Disorders1 80/145 2.52E-39 - -2.26E-07
  Tissue Morphology3 73/943 4.02E-20 - 8.53E-07
  Tissue Development3 68/1374 6.06E-18 - 5.30E-07
  Infectious Disease1 63/1087 1.60E-32 - 1.08E-06
PMA/ionomycin Cancer1 913/2395 5.41E-25 - 5.07E-08
  Cellular Growth and Proliferation2 826/2404 3.15E-48 - 1.18E-08
  Cell Death2 725/2259 1.10E-32 - 5.07E-08
  Cellular Development2 491/1899 3.61E-32 - 4.90E-08
  Hematological System Development and Function3 481/1446 1.34E-35 - 4.73E-08
  Immune Response3 451/475 1.34E-35 - 4.73E-08
  Immunological Disease1 433/1730 1.83E-52 - 3.92E-08
  Immune and Lymphatic System Development and Function3 415/430 1.34E-35 - 2.91E-08
  Inflammatory Disease1 377/401 5.57E-36 - 4.26E-09
  Cell Cycle2 360/1017 4.35E-26 - 4.78E-08
  Skeletal and Muscular Disorders1 327/2024 5.57E-36 - 3.41E-08
  Tissue Morphology3 313/943 1.10E-32 - 2.30E-08
  Connective Tissue Disorders1 294/145 5.57E-36 - 5.29E-09
  Organismal Survival3 290/971 1.10E-15 - 2.41E-08
  Protein Synthesis2 242/534 1.30E-29 - 6.66E-09
  1. 1 Diseases and Disorders
  2. 2 Molecular and Cellular Functions
  3. 3 Physiological System Development and Function
  4. 4 Number of genes found differentially expressed after LPS or PMA/ionomycin stimulation divided by the total number of genes represented on the array for the biological functions