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Table 4 LPS and PMA/ionomycin stimulation: top biological functions from the catalogs Diseases and Disorders1, Molecular and Cellular Functions2 and Physiological System Development and Function3 identified by IPA and number of focus genes

From: Transcriptome analysis of porcine PBMCs after in vitro stimulation by LPS or PMA/ionomycin using an expression array targeting the pig immune response

Stimulation

Top biological functions

# genes4

Fisher p-value

LPS

Cellular Growth and Proliferation2

126/2404

2.25E-18 - 7.17E-07

 

Cell Death2

114/2259

2.00E-27 - 9.59E-07

 

Immunological Disease1

113/1730

3.40E-46 - 9.59E-07

 

Immune Response3

113/475

6.00E-23 - 9.56E-07

 

Inflammatory Disease1

108/401

2.58E-45 - 1.06E-06

 

Hematological System Development and Function3

101/1446

6.70E-28 - 8.53E-07

 

Cell-To-Cell Signaling and Interaction2

99/1465

2.44E-24 - 4.29E-07

 

Cellular Movement2

92/1364

6.70E-28 - 8.33E-07

 

Immune and Lymphatic System Development and Function3

92/430

3.43E-19 - 8.03E-07

 

Skeletal and Muscular Disorders1

83/2024

2.52E-39 - -2.26E-07

 

Cellular Development2

82/1899

1.66E-15 - 1.08E-06

 

Connective Tissue Disorders1

80/145

2.52E-39 - -2.26E-07

 

Tissue Morphology3

73/943

4.02E-20 - 8.53E-07

 

Tissue Development3

68/1374

6.06E-18 - 5.30E-07

 

Infectious Disease1

63/1087

1.60E-32 - 1.08E-06

PMA/ionomycin

Cancer1

913/2395

5.41E-25 - 5.07E-08

 

Cellular Growth and Proliferation2

826/2404

3.15E-48 - 1.18E-08

 

Cell Death2

725/2259

1.10E-32 - 5.07E-08

 

Cellular Development2

491/1899

3.61E-32 - 4.90E-08

 

Hematological System Development and Function3

481/1446

1.34E-35 - 4.73E-08

 

Immune Response3

451/475

1.34E-35 - 4.73E-08

 

Immunological Disease1

433/1730

1.83E-52 - 3.92E-08

 

Immune and Lymphatic System Development and Function3

415/430

1.34E-35 - 2.91E-08

 

Inflammatory Disease1

377/401

5.57E-36 - 4.26E-09

 

Cell Cycle2

360/1017

4.35E-26 - 4.78E-08

 

Skeletal and Muscular Disorders1

327/2024

5.57E-36 - 3.41E-08

 

Tissue Morphology3

313/943

1.10E-32 - 2.30E-08

 

Connective Tissue Disorders1

294/145

5.57E-36 - 5.29E-09

 

Organismal Survival3

290/971

1.10E-15 - 2.41E-08

 

Protein Synthesis2

242/534

1.30E-29 - 6.66E-09

  1. 1 Diseases and Disorders
  2. 2 Molecular and Cellular Functions
  3. 3 Physiological System Development and Function
  4. 4 Number of genes found differentially expressed after LPS or PMA/ionomycin stimulation divided by the total number of genes represented on the array for the biological functions
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BMC Genomics

ISSN: 1471-2164

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