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Table 5 List of KEGG biological pathways associated with the genes differentially expressed after LPS or PMA/ionomycin stimulation

From: Transcriptome analysis of porcine PBMCs after in vitro stimulation by LPS or PMA/ionomycin using an expression array targeting the pig immune response

Stimulation KEGG pathway Symbol # genes1 Fisher p value
LPS Cytokine-cytokine receptor interaction CCRI 29/233 1.00E-08
  Antigen processing and presentation AP_&_P 15/57 3.10E-07
  Toll-like receptor signaling pathway TLR 15/89 1.88E-06
  Cell adhesion molecules CAMs 13/120 6.85E-04
  Hematopoietic cell lineage HCL 13/83 9.03E-06
  Apoptosis Apop 11/76 1.41E-04
  Type I diabetes mellitus T1D 10/31 1.88E-06
  B cell receptor signaling pathway B_cell 8/67 1.60E-03
  Adipocytokine signaling pathway Adip 7/58 1.25E-02
  Small cell lung cancer SCLC 7/126 3.21E-02
  T cell receptor signaling pathway T_cell 7/99 4.37E-02
  Complement and coagulation cascades CCC 6/69 3.30E-02
  Epithelial cell signaling in Helicobacter pylori infection ECs 6/59 3.10E-02
  Acute myeloid leukemia AML 5/53 4.84E-02
  Bladder cancer BC 5/39 1.49E-02
  Alzheimer's disease AD 4/122 1.55E-02
PMA/ionomycin Cytokine-cytokine receptor interaction CCRI 74/233 4.86E-02
  Oxidative phosphorylation OP 63/96 0.00E+00
  Ribosome Ribosome 55/78 0.00E+00
  Cell adhesion molecules CAMs 47/120 1.98E-03
  Jak-STAT signaling pathway Jak-STAT 46/129 4.96E-02
  Natural killer cell mediated cytotoxicity NK 44/102 9.13E-03
  Cell cycle Cell_cycle 41/93 3.11E-03
  Toll-like receptor signaling pathway TLR 40/89 4.14E-04
  Leukocyte transendothelial migration LTEM 39/108 1.36E-02
  Hematopoietic cell lineage HCL 38/83 5.22E-05
  T cell receptor signaling pathway T_cell 38/99 2.16E-04
  Antigen processing and presentation AP_&_P 37/57 7.05E-05
  Chronic myeloid leukemia CML 30/64 1.88E-03
  Pyrimidine metabolism Pyrimidine 30/68 2.07E-02
  TGF-beta signaling pathway TGF-beta 30/69 2.82E-02
  B cell receptor signaling pathway B_cell 28/67 3.85E-04
  Adherens junction AJ 25/68 4.27E-02
  Fc epsilon RI signaling pathway FeRI 25/66 4.27E-02
  Adipocytokine signaling pathway Adip 24/584 4.65E-02
  Renal cell carcinoma RCC 24/62 2.84E-02
  Acute myeloid leukemia AML 23/53 4.47E-03
  Glycolysis/Gluconeogenesis Glycolysis 23/40 1.76E-02
  Pathogenic Escherichia coli infection - EHEC EHEC 21/42 8.24E-03
  Pathogenic Escherichia coli infection - EPEC EPEC 21/42 8.24E-03
  Proteasome Proteasome 21/43 0.00E+00
  Type I diabetes mellitus T1D 18/31 9.62E-03
  Pyruvate metabolism Pyruvate 17/31 1.32E-02
  Neurodegenerative Disorders ND 16/32 1.38E-02
  Aminoacyl-tRNA biosynthesis AA-tRNA 15/28 2.47E-02
  Citrate cycle (TCA cycle) TCA_cycle 13/27 1.12E-02
  Propanoate metabolism Propanoate 13/23 4.57E-02
  Thyroid cancer TC 12/26 2.91E-02
  Prion disease PD 8/34 7.98E-03
  Glycosphingolipid biosynthesis - globoseries Globoseries 7/43 3.12E-02
  Fatty acid elongation in mitochondria FAE 6/10 1.62E-02
  Phenylalanine, tyrosine and tryptophan biosynthesis FYW 5/10 4.18E-02
  Biotin metabolism Biotin 3/7 4.56E-02
  1. 1 Number of genes found differentially expressed after LPS or PMA/ionomycin stimulation divided by the total number of genes represented on the array for the KEGG pathways