Table 5 List of KEGG biological pathways associated with the genes differentially expressed after LPS or PMA/ionomycin stimulation
Stimulation | KEGG pathway | Symbol | # genes1 | Fisher p value |
|---|---|---|---|---|
LPS | Cytokine-cytokine receptor interaction | CCRI | 29/233 | 1.00E-08 |
| Â | Antigen processing and presentation | AP_&_P | 15/57 | 3.10E-07 |
| Â | Toll-like receptor signaling pathway | TLR | 15/89 | 1.88E-06 |
| Â | Cell adhesion molecules | CAMs | 13/120 | 6.85E-04 |
| Â | Hematopoietic cell lineage | HCL | 13/83 | 9.03E-06 |
| Â | Apoptosis | Apop | 11/76 | 1.41E-04 |
| Â | Type I diabetes mellitus | T1D | 10/31 | 1.88E-06 |
| Â | B cell receptor signaling pathway | B_cell | 8/67 | 1.60E-03 |
| Â | Adipocytokine signaling pathway | Adip | 7/58 | 1.25E-02 |
| Â | Small cell lung cancer | SCLC | 7/126 | 3.21E-02 |
| Â | T cell receptor signaling pathway | T_cell | 7/99 | 4.37E-02 |
| Â | Complement and coagulation cascades | CCC | 6/69 | 3.30E-02 |
| Â | Epithelial cell signaling in Helicobacter pylori infection | ECs | 6/59 | 3.10E-02 |
| Â | Acute myeloid leukemia | AML | 5/53 | 4.84E-02 |
| Â | Bladder cancer | BC | 5/39 | 1.49E-02 |
| Â | Alzheimer's disease | AD | 4/122 | 1.55E-02 |
PMA/ionomycin | Cytokine-cytokine receptor interaction | CCRI | 74/233 | 4.86E-02 |
| Â | Oxidative phosphorylation | OP | 63/96 | 0.00E+00 |
| Â | Ribosome | Ribosome | 55/78 | 0.00E+00 |
| Â | Cell adhesion molecules | CAMs | 47/120 | 1.98E-03 |
| Â | Jak-STAT signaling pathway | Jak-STAT | 46/129 | 4.96E-02 |
| Â | Natural killer cell mediated cytotoxicity | NK | 44/102 | 9.13E-03 |
| Â | Cell cycle | Cell_cycle | 41/93 | 3.11E-03 |
| Â | Toll-like receptor signaling pathway | TLR | 40/89 | 4.14E-04 |
| Â | Leukocyte transendothelial migration | LTEM | 39/108 | 1.36E-02 |
| Â | Hematopoietic cell lineage | HCL | 38/83 | 5.22E-05 |
| Â | T cell receptor signaling pathway | T_cell | 38/99 | 2.16E-04 |
| Â | Antigen processing and presentation | AP_&_P | 37/57 | 7.05E-05 |
| Â | Chronic myeloid leukemia | CML | 30/64 | 1.88E-03 |
| Â | Pyrimidine metabolism | Pyrimidine | 30/68 | 2.07E-02 |
| Â | TGF-beta signaling pathway | TGF-beta | 30/69 | 2.82E-02 |
| Â | B cell receptor signaling pathway | B_cell | 28/67 | 3.85E-04 |
| Â | Adherens junction | AJ | 25/68 | 4.27E-02 |
| Â | Fc epsilon RI signaling pathway | FeRI | 25/66 | 4.27E-02 |
| Â | Adipocytokine signaling pathway | Adip | 24/584 | 4.65E-02 |
| Â | Renal cell carcinoma | RCC | 24/62 | 2.84E-02 |
| Â | Acute myeloid leukemia | AML | 23/53 | 4.47E-03 |
| Â | Glycolysis/Gluconeogenesis | Glycolysis | 23/40 | 1.76E-02 |
| Â | Pathogenic Escherichia coli infection - EHEC | EHEC | 21/42 | 8.24E-03 |
| Â | Pathogenic Escherichia coli infection - EPEC | EPEC | 21/42 | 8.24E-03 |
| Â | Proteasome | Proteasome | 21/43 | 0.00E+00 |
| Â | Type I diabetes mellitus | T1D | 18/31 | 9.62E-03 |
| Â | Pyruvate metabolism | Pyruvate | 17/31 | 1.32E-02 |
| Â | Neurodegenerative Disorders | ND | 16/32 | 1.38E-02 |
| Â | Aminoacyl-tRNA biosynthesis | AA-tRNA | 15/28 | 2.47E-02 |
| Â | Citrate cycle (TCA cycle) | TCA_cycle | 13/27 | 1.12E-02 |
| Â | Propanoate metabolism | Propanoate | 13/23 | 4.57E-02 |
| Â | Thyroid cancer | TC | 12/26 | 2.91E-02 |
| Â | Prion disease | PD | 8/34 | 7.98E-03 |
| Â | Glycosphingolipid biosynthesis - globoseries | Globoseries | 7/43 | 3.12E-02 |
| Â | Fatty acid elongation in mitochondria | FAE | 6/10 | 1.62E-02 |
| Â | Phenylalanine, tyrosine and tryptophan biosynthesis | FYW | 5/10 | 4.18E-02 |
| Â | Biotin metabolism | Biotin | 3/7 | 4.56E-02 |