Characterizing Ancylostoma caninum transcriptome and exploring nematode parasitic adaptation

Wang, Zhengyuan; Abubucker, Sahar; Martin, John; Wilson, Richard K; Hawdon, John; Mitreva, Makedonka

doi:10.1186/1471-2164-11-307

BMC Genomics

Table 4 Enriched GO terms associated with transcripts with differential expression patterns

From: Characterizing Ancylostoma caninum transcriptome and exploring nematode parasitic adaptation

Stage	GO id*	GO descriptor	A. caninum trancripts
Female & Male
	GO:0003674	Molecular Function	198
	GO:0004194	pepsin A activity	7
	GO:0004197	cysteine-type endopeptidase activity	16
	GO:0004245	neprilysin activity	6
	GO:0004365	glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity	4
	GO:0004415	hyalurononglucosaminidase activity	2
	GO:0004531	deoxyribonuclease II activity	4
	GO:0004623	phospholipase A2 activity	3
	GO:0004806	triacylglycerol lipase activity	8
	GO:0005529	sugar binding	7
	GO:0008270	zinc ion binding	22
	GO:0008533	astacin activity	19
	GO:0042302	structural constituent of cuticle	7
	GO:0051287	NAD binding	6
Female
	GO:0003674	Molecular Function	52
	GO:0004252	serine-type endopeptidase activity	4
	GO:0004348	glucosylceramidase activity	5
Male
	GO:0003674	Molecular Function	168
	GO:0003735	structural constituent of ribosome	27
	GO:0004396	hexokinase activity	4
	GO:0004672	protein kinase activity	23
	GO:0004674	protein serine/threonine kinase activity	15
	GO:0004867	serine-type endopeptidase inhibitor activity	13
	GO:0005198	structural molecule activity	35
Infective L3 & serum stimulated L3
	GO:0003674	Molecular Function	1388
	GO:0001584	rhodopsin-like receptor activity	43
	GO:0003735	structural constituent of ribosome	89
	GO:0003849	3-deoxy-7-phosphoheptulonate synthase activity	4
	GO:0003924	GTPase activity	23
	GO:0004377	glycolipid 2-alpha-mannosyltransferase activity	4
	GO:0004673	protein histidine kinase activity	5
	GO:0005249	voltage-gated potassium channel activity	8
	GO:0005351	sugar:hydrogen symporter activity	14
	GO:0005525	GTP binding	57
	GO:0008080	N-acetyltransferase activity	14
	GO:0015035	protein disulfide oxidoreductase activity	7
	GO:0016491	oxidoreductase activity	206
	GO:0016564	transcription repressor activity	4
	GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	27
	GO:0016829	lyase activity	43
	GO:0020037	heme binding	35
	GO:0050662	coenzyme binding	44
Infective L3
	GO:0003674	Molecular Function	20
	GO:0004129	cytochrome-c oxidase activity	3
	GO:0005507	copper ion binding	3
	GO:0020037	heme binding	3
Serum stimulated L3
	GO:0003674	Molecular Function	8
	GO:0004806	triacylglycerol lipase activity	2
All stages
	GO:0003674	Molecular Function	3052
	GO:0003676	nucleic acid binding	558
	GO:0003700	transcription factor activity	85
	GO:0003707	steroid hormone receptor activity	30
	GO:0003723	RNA binding	96
	GO:0003924	GTPase activity	44
	GO:0004000	adenosine deaminase activity	6
	GO:0004674	protein serine/threonine kinase activity	95
	GO:0004713	protein tyrosine kinase activity	77
	GO:0005515	protein binding	381
	GO:0008026	ATP-dependent helicase activity	33
	GO:0008138	protein tyrosine/serine/threonine phosphatase activity	12
	GO:0008270	zinc ion binding	258
	GO:0008508	bile acid:sodium symporter activity	4
	GO:0008705	methionine synthase activity	4
	GO:0017111	nucleoside-triphosphatase activity	188
	GO:0019787	small conjugating protein ligase activity	39
	GO:0031072	heat shock protein binding	23
	GO:0046983	protein dimerization activity	19

* Only Go terms with more than 50 hits to Mol. Function are presented.
Cut-offs: FRD < 0.1; hypogeometrics test P < 0.05.

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ISSN: 1471-2164

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