Table 1 List of 66 genes modulated in PSs classified by their function.
FUNCTION | Gene Name | Symbol | PCSC | LNCaP | |
|---|---|---|---|---|---|
Adhesion | Cell-Cell | major histocompatibility complex, class II, DM alpha | HLA-DMA | 2.0 | 2.2 |
cadherin 3, type 1, P-cadherin (placental) | CDH3 | 2.1 | 2.0 | ||
HLA complex group 4 | HCG4 | -1.9 | -1.9 | ||
activated leukocyte cell adhesion molecule | ALCAM | -2.3 | -2.3 | ||
Cell-Matrix | Kallmann syndrome 1 sequence | KAL1 | -2.0 | -2.2 | |
Extracellular matrix | collagen, type VI, alpha 1 | COL6A1 | 1.8 | 2.7 | |
Tight junction | claudin 3 | CLDN3 | 2.1 | 1.9 | |
Cell cycle | Protein biosynthesis | MYC induced nuclear antigen | MINA | -1.9 | -1.9 |
Regulation | cyclin E2 | CCNE2 | -2.1 | -2.7 | |
Cytoskeleton | Actin binding | tropomyosin 1 (alpha) | TPM1 | -2.4 | -2.1 |
gelsolin (amyloidosis, Finnish type) | GSN | 2.1 | 1.9 | ||
Regulation | Src homology 3 | SGEF | -2.4 | -2.1 | |
Growth factor | Receptor | neuropilin 1 | NRP1 | 8.7 | 2.8 |
Secreted | growth differentiation factor 15 | GDF15 | 8.0 | 2.2 | |
Metabolism | Metals | metallothionein 1G | MT1G | -4.1 | -1.9 |
metallothionein 1H | MT1H | -4.4 | -1.8 | ||
metallothionein 2A | MT2A | -4.8 | -1.8 | ||
Carbohydrate | UDP-N-acteylglucosamine pyrophosphorylase 1 | UAP1 | -3.1 | -2.1 | |
DNA | RAD18 homolog (S. cerevisiae) | RAD18 | -1.9 | -1.9 | |
Enzyme | methionine sulfoxide reductase B3 | MSRB3 | -2.1 | -2.4 | |
Hormone | membrane metallo-endopeptidase | MME | -3.0 | -2.5 | |
Sugar biosynthesis | lectin galactoside-binding 8 galectins | LGALS8 | -2.2 | -2.0 | |
mannosidase, alpha, class 1C, member 1 | MAN1C1 | 1.9 | 1.8 | ||
Protein biosynthesis | STAM binding protein-like 1 | STAMBPL1 | -2.0 | -2.1 | |
cysteinyl-tRNA synthetase | CARS | -2.2 | -1.9 | ||
glycyl-tRNA synthetase | GARS | -2.2 | -2.1 | ||
tryptophanyl-tRNA synthetase | WARS | -2.5 | -2.8 | ||
heat shock 60 kDa protein 1 (chaperonin) | HSPD1 | -2.1 | -3.4 | ||
Protein stability | YOD1 OTU deubiquinating enzyme 1 homolog | YOD1 | -2.0 | -2.1 | |
Protein binding | tissue factor pathway inhibitor | TFPI | 2.4 | 1.8 | |
neuron navigator 3 | NAV3 | -5.5 | -2.3 | ||
Signaling | Hormone | relaxin 2 | RLN2 | -1.8 | -2.0 |
Hormone Receptor | prostaglandin E receptor 4 (subtype EP4) | PTGER4 | -3.6 | -2.9 | |
Integrin | sema, immunoglobulin (Ig) and short basic domain | SEMA3B | 1.9 | 1.8 | |
Kinase | dual specificity phosphatase 6 | DUSP6 | 2.0 | 2.2 | |
Ligand | jagged 1 (Alagille syndrome) | JAG1 | 4.0 | 3.2 | |
Membrane traffic | synaptojanin 2 | SYNJ2 | -2.0 | -2.3 | |
Secreted | clusterin | CLU | 2.8 | 2.3 | |
amyloid beta (A4) precursor-like protein 2 | APLP2 | 2.7 | 2.0 | ||
c-mer proto-oncogene tyrosine kinase | MERTK | 2.1 | 2.0 | ||
RIO kinase 3 (yeast) | RIOK3 | -1.9 | -2.2 | ||
Transcription | Activator | c-myc binding protein | MYCBP | -2.4 | -2.4 |
Activator | v-myb myeloblastosis viral oncogene homolog (avian)-like 1 | MYBL1 | -3.4 | -2.0 | |
Inhibitor | inhibitor of DNA binding 3 | ID3 | -6.7 | -3.1 | |
Inhibitor | inhibitor of DNA binding 1 | ID1 | -10.2 | -5.2 | |
E74-like factor 3 | ELF3 | 2.0 | 2.5 | ||
v-fos FBJ murine osteosarcoma viral oncogene homolog | FOS | 4.8 | 2.5 | ||
Kruppel-like factor 2 (lung) | KLF2 | 2.1 | 1.8 | ||
CCAAT/enhancer binding protein (C/EBP), gamma | CEBPG | -1.9 | -2.0 | ||
E74-like factor 4 (ets domain transcription factor) | ELF4 | -2.3 | -1.9 | ||
zinc finger and BTB domain containing 38 | ZBTB38 | -2.5 | -2.0 | ||
Kruppel-like factor 5 (intestinal) | KLF5 | -2.8 | -2.0 | ||
Translation | regulation | quaking homolog, KH domain RNA binding (mouse) | QKI | -2.9 | -1.9 |
eukaryotic translation initiation factor 2, subunit 1 alpha | EIF2S1 | -1.9 | -2.0 | ||
Transport | Integral | Transmembrane channel-like 4 | TMC4 | 1.8 | 2.2 |
Zinc | solute carrier family 39 (zinc transporter), member 10 | SLC39A10 | 2.3 | 2.5 | |
solute carrier family 25, member 30 | SLC25A30 | -1.8 | -2.3 | ||
solute carrier family 7, member 5 | SLC7A5 | -2.3 | -2.3 | ||
Hbc647 mRNA sequence | SLC30A1 | -12.8 | -2.3 | ||
Unknown | FLJ35024, C3orf59, CCDC113, C5orf35, CCDC50, CCDC76, LOC440731 |