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Table 1 List of 66 genes modulated in PSs classified by their function.

From: Genomic profiling of tumor initiating prostatospheres

FUNCTION   Gene Name Symbol PCSC LNCaP
Adhesion Cell-Cell major histocompatibility complex, class II, DM alpha HLA-DMA 2.0 2.2
   cadherin 3, type 1, P-cadherin (placental) CDH3 2.1 2.0
   HLA complex group 4 HCG4 -1.9 -1.9
   activated leukocyte cell adhesion molecule ALCAM -2.3 -2.3
  Cell-Matrix Kallmann syndrome 1 sequence KAL1 -2.0 -2.2
  Extracellular matrix collagen, type VI, alpha 1 COL6A1 1.8 2.7
  Tight junction claudin 3 CLDN3 2.1 1.9
Cell cycle Protein biosynthesis MYC induced nuclear antigen MINA -1.9 -1.9
  Regulation cyclin E2 CCNE2 -2.1 -2.7
Cytoskeleton Actin binding tropomyosin 1 (alpha) TPM1 -2.4 -2.1
   gelsolin (amyloidosis, Finnish type) GSN 2.1 1.9
  Regulation Src homology 3 SGEF -2.4 -2.1
Growth factor Receptor neuropilin 1 NRP1 8.7 2.8
  Secreted growth differentiation factor 15 GDF15 8.0 2.2
Metabolism Metals metallothionein 1G MT1G -4.1 -1.9
   metallothionein 1H MT1H -4.4 -1.8
   metallothionein 2A MT2A -4.8 -1.8
  Carbohydrate UDP-N-acteylglucosamine pyrophosphorylase 1 UAP1 -3.1 -2.1
  DNA RAD18 homolog (S. cerevisiae) RAD18 -1.9 -1.9
  Enzyme methionine sulfoxide reductase B3 MSRB3 -2.1 -2.4
  Hormone membrane metallo-endopeptidase MME -3.0 -2.5
  Sugar biosynthesis lectin galactoside-binding 8 galectins LGALS8 -2.2 -2.0
   mannosidase, alpha, class 1C, member 1 MAN1C1 1.9 1.8
  Protein biosynthesis STAM binding protein-like 1 STAMBPL1 -2.0 -2.1
   cysteinyl-tRNA synthetase CARS -2.2 -1.9
   glycyl-tRNA synthetase GARS -2.2 -2.1
   tryptophanyl-tRNA synthetase WARS -2.5 -2.8
   heat shock 60 kDa protein 1 (chaperonin) HSPD1 -2.1 -3.4
  Protein stability YOD1 OTU deubiquinating enzyme 1 homolog YOD1 -2.0 -2.1
Protein binding   tissue factor pathway inhibitor TFPI 2.4 1.8
   neuron navigator 3 NAV3 -5.5 -2.3
Signaling Hormone relaxin 2 RLN2 -1.8 -2.0
  Hormone Receptor prostaglandin E receptor 4 (subtype EP4) PTGER4 -3.6 -2.9
  Integrin sema, immunoglobulin (Ig) and short basic domain SEMA3B 1.9 1.8
  Kinase dual specificity phosphatase 6 DUSP6 2.0 2.2
  Ligand jagged 1 (Alagille syndrome) JAG1 4.0 3.2
  Membrane traffic synaptojanin 2 SYNJ2 -2.0 -2.3
  Secreted clusterin CLU 2.8 2.3
   amyloid beta (A4) precursor-like protein 2 APLP2 2.7 2.0
   c-mer proto-oncogene tyrosine kinase MERTK 2.1 2.0
   RIO kinase 3 (yeast) RIOK3 -1.9 -2.2
Transcription Activator c-myc binding protein MYCBP -2.4 -2.4
  Activator v-myb myeloblastosis viral oncogene homolog (avian)-like 1 MYBL1 -3.4 -2.0
  Inhibitor inhibitor of DNA binding 3 ID3 -6.7 -3.1
  Inhibitor inhibitor of DNA binding 1 ID1 -10.2 -5.2
   E74-like factor 3 ELF3 2.0 2.5
   v-fos FBJ murine osteosarcoma viral oncogene homolog FOS 4.8 2.5
   Kruppel-like factor 2 (lung) KLF2 2.1 1.8
   CCAAT/enhancer binding protein (C/EBP), gamma CEBPG -1.9 -2.0
   E74-like factor 4 (ets domain transcription factor) ELF4 -2.3 -1.9
   zinc finger and BTB domain containing 38 ZBTB38 -2.5 -2.0
   Kruppel-like factor 5 (intestinal) KLF5 -2.8 -2.0
Translation regulation quaking homolog, KH domain RNA binding (mouse) QKI -2.9 -1.9
   eukaryotic translation initiation factor 2, subunit 1 alpha EIF2S1 -1.9 -2.0
Transport Integral Transmembrane channel-like 4 TMC4 1.8 2.2
  Zinc solute carrier family 39 (zinc transporter), member 10 SLC39A10 2.3 2.5
   solute carrier family 25, member 30 SLC25A30 -1.8 -2.3
   solute carrier family 7, member 5 SLC7A5 -2.3 -2.3
   Hbc647 mRNA sequence SLC30A1 -12.8 -2.3
Unknown   FLJ35024, C3orf59, CCDC113, C5orf35, CCDC50, CCDC76, LOC440731    
  1. prostatospheres classified by their function.