Skip to main content

Table 4 Top canonical metabolic and signaling (in bold font) pathways uncovered by Ingenuity Pathway Analysis® (Benjamini-Hochberg FDR ≤ 0.05) within differentially expressed genes (DEG) with > 1.5-fold mRNA abundance between parenchyma and fat pad in mammary gland from pre-weaned Holstein heifers.

From: Functional and gene network analyses of transcriptional signatures characterizing pre-weaned bovine mammary parenchyma or fat pad uncovered novel inter-tissue signaling networks during development

Pathway P-value FDR # DEG
DEG highly-expressed in parenchyma vs. fat pad    
   Cell Cycle: G2/M DNA Damage Checkpoint Regulation 0.0025 0.114 7
   Nitric Oxide Signaling in the Cardiovascular System 0.0028 0.114 9
   Actin Cytoskeleton Signaling 0.0001 0.014 22
   p53 Signaling 0.0014 0.114 11
   Wnt/β-catenin Signaling 0.0071 0.193 15
   PI3K/AKT Signaling 0.0071 0.193 13
DEG highly-expressed in fat pad vs. parenchyma1    
   Propanoate Metabolism 0.0000 0.000 12
   Metabolism of Xenobiotics by Cytochrome P450 0.0000 0.001 11
   Valine, Leucine and Isoleucine Degradation 0.0000 0.001 11
   Butanoate Metabolism 0.0001 0.002 10
   Glutathione Metabolism 0.0001 0.002 9
   Pyruvate Metabolism 0.0001 0.002 11
   Fatty Acid Metabolism 0.0003 0.004 12
   Citrate Cycle 0.0003 0.004 7
   Glycolysis/Gluconeogenesis 0.0009 0.009 11
   Synthesis and Degradation of Ketone Bodies 0.0020 0.016 4
   Fatty Acid Elongation in Mitochondria 0.0030 0.022 4
   Oxidative Phosphorylation 0.0085 0.055 13
   Tryptophan Metabolism 0.0087 0.055 9
   Pentose Phosphate Pathway 0.0098 0.056 5
   Mitochondrial Dysfunction 0.0000 0.000 19
   LPS/IL-1 Mediated Inhibition of RXR Function 0.0000 0.000 20
   Xenobiotic Metabolism Signaling 0.0000 0.001 23
   Aryl Hydrocarbon Receptor Signaling 0.0001 0.001 17
   Acute Phase Response Signaling 0.0003 0.004 19
   LXR/RXR Activation 0.0004 0.005 10
   Complement System 0.0004 0.005 7
   TR/RXR Activation 0.0013 0.012 11
   α-Adrenergic Signaling 0.0013 0.012 12
   NRF2-mediated Oxidative Stress Response 0.0014 0.012 18
   Cardiac β-Adrenergic Signaling 0.0014 0.012 13
   cAMP-mediated Signaling 0.0055 0.038 13
   IL-8 Signaling 0.0081 0.055 16
   IGF-1 Signaling 0.0098 0.118 11
  1. 1Reported also are the pathways with Benjamini-Hochberg FDR ≤ 0.12.