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Table 2 Gene ontology (GO) analysis of differentially expressed genes listed in the Additional file 2

From: Transcriptomic analysis of dystrophin RNAi knockdown reveals a central role for dystrophin in muscle differentiation and contractile apparatus organization

Category Term Genes FE p val. Adj. p val.
Cellular Component GO:0044449 contractile fiber part OBSCN, DMN, DMD, MYBPC2, TCAP, MYH13, MYH1, LDB3, ACTN3, MYBPC3, MYH7, PYGM, MYH4, TPM3, 13.83 1.74E-11 6.77E-09
Cellular Component GO:0030017 sarcomere OBSCN, DMN, DMD, MYBPC2, TCAP, MYH13, MYH1, LDB3, ACTN3, MYBPC3, MYH7, PYGM, MYH4, TPM3, 14.25 1.16E-11 9.06E-09
Cellular Component GO:0030016 myofibril OBSCN, DMN, DMD, MYBPC2, TCAP, MYH13, MYH1, LDB3, ACTN3, MYBPC3, MYH7, PYGM, MYH4, TPM3, 12.89 4.47E-11 1.16E-08
Cellular Component GO:0043292 contractile fiber OBSCN, DMN, DMD, MYBPC2, TCAP, MYH13, MYH1, LDB3, ACTN3, MYBPC3, MYH7, PYGM, MYH4, TPM3, 12.38 7.61E-11 1.48E-08
Cellular Component GO:0005863 striated muscle thick filament MYH7, OBSCN, MYH4, MYBPC2, MYH13, MYH1, MYBPC3, 36.18 1.55E-08 2.01E-06
Cellular Component GO:0032982 myosin filament MYH7, OBSCN, MYH4, MYBPC2, MYH13, MYH1, MYBPC3, 36.18 1.55E-08 2.01E-06
Cellular Component GO:0005859 muscle myosin complex MYH7, OBSCN, MYH4, MYBPC2, MYH13, MYH1, MYBPC3, 33.60 2.67E-08 2.98E-06
Cellular Component GO:0016460 myosin II complex MYH7, OBSCN, MYH4, MYBPC2, MYH13, MYH1, MYBPC3, 29.40 6.95E-08 6.78E-06
Molecular Function GO:0008092 cytoskeletal protein binding OBSCN, DMD, MYBPC2, MYH13, MYH1, ACTN3, EPB4.1L4B, MYBPC3, DCX, MTAP7, MYH7, MYH4, MYOZ1, TMOD4, PACSIN1, PSTPIP2, TPM3, SCIN, CFL2, SPNB1, 3.79 1.37E-06 3.63E-03
Cellular Component GO:0030018 Z disc DMN, OBSCN, PYGM, DMD, TCAP, LDB3, 13.44 7.16E-05 5.57E-03
Cellular Component GO:0031674 I band DMN, OBSCN, PYGM, DMD, TCAP, LDB3, 11.52 1.54E-04 1.08E-02
Cellular Component GO:0005856 cytoskeleton DMN, OBSCN, TTL, MYBPC2, MYH13, MYH1, ABI2, ACTN3, EPB4.1L4B, MTAP7, KRT18, TMOD4, PSTPIP2, CFL2, TPM3, DYNLRB2, GAN, DMD, LDB3, MYBPC3, DCX, MYH7, SGCG, KY, MYH4, MYOZ1, SCIN, SPNB1, 2.16 2.14E-04 1.27E-02
Cellular Component GO:0016459 myosin complex MYH7, OBSCN, MYH4, MYBPC2, MYH13, MYH1, MYBPC3, 8.11 2.09E-04 1.35E-02
Biological Process GO:0003012 muscle system process MYH7, MYH4, MYBPC2, CASQ1, KCNMA1, MYH13, MYH1, TPM3, ACTN3, MYBPC3, 7.63 5.92E-06 1.51E-02
Biological Process GO:0006936 muscle contraction MYH7, MYH4, MYBPC2, CASQ1, KCNMA1, MYH13, MYH1, TPM3, ACTN3, MYBPC3, 7.63 5.92E-06 1.51E-02
Molecular Function GO:0031420 alkali metal ion binding KCNC1, KCNA7, SCN3B, SCN1B, TTL, SLC9A7, ATP1B2, IMPA2, KCNMA1, KCNK3, SLC24A5, GMPR, 4.82 3.95E-05 5.10E-02
Molecular Function GO:0030955 potassium ion binding KCNC1, KCNA7, TTL, SLC9A7, ATP1B2, KCNMA1, KCNK3, SLC24A5, GMPR, 6.08 1.13E-04 7.22E-02
Molecular Function GO:0003779 actin binding DMD, MYBPC2, MYH13, MYH1, ACTN3, MYBPC3, MYH7, MYH4, TMOD4, PSTPIP2, TPM3, SCIN, CFL2, SPNB1, 3.77 8.93E-05 7.59E-02
  1. DAVID tool was used for this analysis. Only terms with Benjamini-Hochberg adjusted p values < 0.1 and Fold Enrichment (FE) greater than 2 are displayed. Table sorted by ascending adjusted p values.
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BMC Genomics

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