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Table 7 Summary of TFAP2A-down-modulated genes containing SP1 binding sites in their promoters

From: Identification of functional TFAP2A and SP1 binding sites in new TFAP2A-modulated genes

Down-modulated genes containing SP-1 binding sites

ENSEMBL ID

Gene symbol

Microarray FC

Oligo

oPOSSUM

MEME

ENSG00000092871

RFFL

-1.5

-

-

-

ENSG00000

SLCO4

-1.5

-

-

-

ENSG00000

C16or

-1.5

-

+

-

ENSG00000

CDK6

-1.5

-

+

-

ENSG00000

GCN5L

-1.5

-

+

-

ENSG00000

ATP8B

-1.5

-

-

-

ENSG00000

CASP9

-1.5

+

-

-

ENSG00000

SPOCK

-1.5

+

+

-

ENSG00000

FBN1

-1.5

-

+

-

ENSG00000

SMAD3

-1.5

+

+

-

ENSG00000

PHLDA

-1.5

-

+

-

ENSG00000

DALRD

-1.5

+

+

-

ENSG00000

GPRC5

-1.6

-

-

+

ENSG00000

KIAA1

-1.6

-

-

-

ENSG00000

COL12

-1.6

-

+

-

ENSG00000

TGFBI

-1.6

-

-

-

ENSG00000

RDH10

-1.6

+

+

-

ENSG00000

MESP1

-1.6

-

-

-

ENSG00000

OPLAH

-1.6

+

+

-

ENSG00000

ST4S6

-1.6

-

+

+

ENSG00000

BCOR

-1.6

+

+

-

ENSG00000

RPS27

-1.6

-

+

+

ENSG00000

SLC25

-1.6

+

-

-

ENSG00000

PDGFA

-1.6

+

+

-

ENSG00000

DNMT3

-1.7

-

+

-

ENSG00000

EPB41

-1.7

+

+

-

ENSG00000

CDKN1

-1.7

+

+

-

ENSG00000

TMEM1

-1.7

-

+

-

ENSG00000

RNF38

-1.7

-

-

-

ENSG00000

SLC27

-1.7

+

-

-

ENSG00000

SLC43

-1.7

+

+

-

ENSG00000

DPYSL

-1.8

-

+

-

ENSG00000

SLC7A

-1.8

-

-

-

ENSG00000

PXDN

-1.8

-

-

-

ENSG00000

COL5A

-1.8

+

+

-

ENSG00000

SECTM

-1.8

+

-

-

ENSG00000

GLS

-1.9

-

+

-

ENSG00000

ENAH

-1.9

-

+

-

ENSG00000

FTH1

-1.9

-

-

-

ENSG00000

SYNGR

-2.0

-

+

+

ENSG00000

TXNIP

-2.0

-

+

-

ENSG00000

LOXL2

-2.0

-

-

-

ENSG00000

STX6

-2.0

-

+

+

ENSG00000

RAB15

-2.0

+

-

-

ENSG00000

COX6B

-2.0

-

-

-

ENSG00000

OLFML

-2.0

+

+

+

ENSG00000

PAG1

-2.1

-

+

-

ENSG00000

SESN1

-2.1

-

+

-

ENSG00000

ACTA2

-2.1

-

-

-

ENSG00000

ANXA8

-2.2

-

-

-

ENSG00000

ZFAND

-2.3

-

+

-

ENSG00000

KRT16

-2.5

-

+

-

ENSG00000

JMJD3

-2.6

-

+

-

ENSG00000

PLSCR

-2.7

+

-

+

ENSG00000

USP18

-2.7

-

-

+

ENSG00000

KRT17

-2.7

-

-

-

ENSG00000127129

EDN2

-3.2

-

+

-

  1. A search for SP1 Transcription Factor Binding Sites (TFBS) was performed on the promoter regions (-900/+100) of 157 TFAP2A-down-modulated genes [39], mapped in ENSEMBL, containing at least one or two best 20% TFAP2A binding sites (see Table 1) using the SP1 Positional Weight Matrix (PWM) provided by Jaspar. 57 genes containing SP1 TFBS were identified. The outcome obtained with the Oligo, oPOSSUM and MEME analyses are also indicated (see Table 4, 5, 6).