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Table 7 Summary of TFAP2A-down-modulated genes containing SP1 binding sites in their promoters

From: Identification of functional TFAP2A and SP1 binding sites in new TFAP2A-modulated genes

Down-modulated genes containing SP-1 binding sites
ENSEMBL ID Gene symbol Microarray FC Oligo oPOSSUM MEME
ENSG00000092871 RFFL -1.5 - - -
ENSG00000 SLCO4 -1.5 - - -
ENSG00000 C16or -1.5 - + -
ENSG00000 CDK6 -1.5 - + -
ENSG00000 GCN5L -1.5 - + -
ENSG00000 ATP8B -1.5 - - -
ENSG00000 CASP9 -1.5 + - -
ENSG00000 SPOCK -1.5 + + -
ENSG00000 FBN1 -1.5 - + -
ENSG00000 SMAD3 -1.5 + + -
ENSG00000 PHLDA -1.5 - + -
ENSG00000 DALRD -1.5 + + -
ENSG00000 GPRC5 -1.6 - - +
ENSG00000 KIAA1 -1.6 - - -
ENSG00000 COL12 -1.6 - + -
ENSG00000 TGFBI -1.6 - - -
ENSG00000 RDH10 -1.6 + + -
ENSG00000 MESP1 -1.6 - - -
ENSG00000 OPLAH -1.6 + + -
ENSG00000 ST4S6 -1.6 - + +
ENSG00000 BCOR -1.6 + + -
ENSG00000 RPS27 -1.6 - + +
ENSG00000 SLC25 -1.6 + - -
ENSG00000 PDGFA -1.6 + + -
ENSG00000 DNMT3 -1.7 - + -
ENSG00000 EPB41 -1.7 + + -
ENSG00000 CDKN1 -1.7 + + -
ENSG00000 TMEM1 -1.7 - + -
ENSG00000 RNF38 -1.7 - - -
ENSG00000 SLC27 -1.7 + - -
ENSG00000 SLC43 -1.7 + + -
ENSG00000 DPYSL -1.8 - + -
ENSG00000 SLC7A -1.8 - - -
ENSG00000 PXDN -1.8 - - -
ENSG00000 COL5A -1.8 + + -
ENSG00000 SECTM -1.8 + - -
ENSG00000 GLS -1.9 - + -
ENSG00000 ENAH -1.9 - + -
ENSG00000 FTH1 -1.9 - - -
ENSG00000 SYNGR -2.0 - + +
ENSG00000 TXNIP -2.0 - + -
ENSG00000 LOXL2 -2.0 - - -
ENSG00000 STX6 -2.0 - + +
ENSG00000 RAB15 -2.0 + - -
ENSG00000 COX6B -2.0 - - -
ENSG00000 OLFML -2.0 + + +
ENSG00000 PAG1 -2.1 - + -
ENSG00000 SESN1 -2.1 - + -
ENSG00000 ACTA2 -2.1 - - -
ENSG00000 ANXA8 -2.2 - - -
ENSG00000 ZFAND -2.3 - + -
ENSG00000 KRT16 -2.5 - + -
ENSG00000 JMJD3 -2.6 - + -
ENSG00000 PLSCR -2.7 + - +
ENSG00000 USP18 -2.7 - - +
ENSG00000 KRT17 -2.7 - - -
ENSG00000127129 EDN2 -3.2 - + -
  1. A search for SP1 Transcription Factor Binding Sites (TFBS) was performed on the promoter regions (-900/+100) of 157 TFAP2A-down-modulated genes [39], mapped in ENSEMBL, containing at least one or two best 20% TFAP2A binding sites (see Table 1) using the SP1 Positional Weight Matrix (PWM) provided by Jaspar. 57 genes containing SP1 TFBS were identified. The outcome obtained with the Oligo, oPOSSUM and MEME analyses are also indicated (see Table 4, 5, 6).