Table 2 DAVID analysis of pathways significantly enriched in the list of differentially expressed genes
From: Muscle transcriptomic profiles in pigs with divergent phenotypes for fatness traits
KEGG id | KEGG pathway name | Genes (n) | Genes | Fold† | p-value* |
|---|---|---|---|---|---|
►01040 | Polyunsaturated fatty acids biosynthesis | 7 | SCD, TECR, ELOVL5, ELOVL6, FASN, PTPLB, ACAA1 | 8.3046 | 0.00001 |
05222 | Small cell lung cancer | 15 | LAMB1, PIK3CA, LAMA5, LAMA2, CYCS, BIRC3, MAX, PIK3R1, ITGB1, COL4A1, ITGAV, CKS1B, LAMC2, BIRC4, RXRG | 3.2728 | 0.0001 |
04612 | Antigen processing and presentation | 12 | HSPA2, HSPA4, HLA-A, PSME1, HSP90AA1, TAPBP, HLA-DRA, B2M, HLA-G, CD74, NFYA, HLA-DMB | 2.8473 | 0.0027 |
04510 | Focal adhesion | 21 | PIK3CA, LAMB1, LAMA5, VEGFA, LAMA2, RAP1A, COL5A3, BIRC3, PIK3R1, ITGB1, IGF1R, COL4A1, ITGB3, THBS4, ITGAV, CAV1, LAMC2, EGFR, BIRC4, ROCK1, ROCK2 | 2.0031 | 0.0034 |
►04910 | Insulin signalling pathway | 15 | PIK3CA, ACACA, PPARGC1A, RHOQ, EIF4E, LIPE, PIK3R1, PRKAR2B, IRS2, PPP1R3B, FASN, SORBS1, PRKAB2, IRS1, PRKAG2 | 2.1248 | 0.0097 |
►03320 | PPAR signalling pathway | 9 | SCD, OLR1, FABP4, PPARG, ADIPOQ, ACAA1, RXRG, PPARD, SORBS1 | 2.3727 | 0.0334 |
►04512 | ECM-receptor interaction | 10 | LAMB1, LAMA5, THBS4, ITGAV, LAMA2, COL5A3, LAMC2, ITGB1, COL4A1, ITGB3 | 2.1570 | 0.0396 |
►04070 | Phosphatidylinositol signalling system | 9 | PIK3CA, ITPR1, DGKZ, SYNJ1, PLCD4, FN3K, PIK3R1, PIK3C2A, DGKG | 2.2479 | 0.0444 |
04150 | mTOR signalling pathway | 7 | ULK2, PIK3CA, VEGFA, EIF4E, PIK3R1, ULK3, RICTOR | 2.6054 | 0.0488 |
►04930 | Type II diabetes mellitus | 6 | PIK3CA, IRS2, CACNA1C, ADIPOQ, PIK3R1, IRS1 | 2.5309 | 0.0844 |
►04920 | Adipocytokine signalling pathway | 8 | IRS2, PPARGC1A, ADIPOQ, ADIPOR2, RXRG, IRS1, PRKAB2, PRKAG2 | 2.0802 | 0.0862 |
►04350 | TGF-beta signalling pathway | 9 | BMP5, FST, THBS4, CUL1, ZFYVE16, TGFB2, ROCK1, SMAD5, ROCK2 | 1.8982 | 0.0978 |