Table 2 Gene ontology analysis of genes expressed at lower levels in CD34+ cells
Molecular Function | # genes | P-value |
|---|---|---|
Membrane traffic protein | 63 | 2.40E-13 |
Nucleic acid binding | 280 | 4.89E-09 |
Select regulatory molecule | 137 | 4.40E-07 |
Vesicle coat protein | 16 | 1.53E-05 |
Chaperone | 33 | 2.31E-05 |
Other chaperones | 21 | 2.55E-05 |
Other transcription factor | 50 | 3.29E-04 |
Ligase | 59 | 6.84E-04 |
Miscellaneous function | 95 | 7.58E-04 |
Ubiquitin-protein ligase | 36 | 4.15E-03 |
Transporter | 69 | 1.61E-02 |
Phosphatase | 34 | 2.13E-02 |
Other RNA-binding protein | 29 | 2.35E-02 |
mRNA processing factor | 24 | 2.80E-02 |
Transferase | 87 | 3.26E-02 |
G-protein modulator | 49 | 4.85E-02 |
Other transporter | 42 | 4.89E-02 |
Pathway | # genes | P-value |
Apoptosis signaling pathway | 36 | 3.02E-09 |
Ubiquitin proteasome pathway | 22 | 1.34E-04 |
Huntington disease | 28 | 1.10E-02 |
Ras Pathway | 18 | 2.17E-02 |
Transcription regulation by bZIP transcription factor | 17 | 3.32E-02 |
PDGF signaling pathway | 28 | 4.99E-02 |