SeqA binding to the E. coli chromosome. A Whole genome plot of the SeqA ChIP signal with the modified method (outer red circle) in comparison to the SeqA ChIP signal resulting from old method (grey, compare fig. 2). The inner red circle is the sum of SeqA ChIP signals in windows of 60.000 bp (only positive values were included). B Correlation of SeqA ChIP signal with number of GATC sites per 500 bp (see legend to Fig. 2).