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Table 1 Microarray Data Used In This Study

From: A systems approach to mapping transcriptional networks controlling surfactant homeostasis

Array Name

Investigator

Mouse Model

Reference

CEBPA_KO

Ikegami

Cebpa Δ/Δ mice: (tetO)7CMV-Cre-/tg/SP-C-rtTA-/tg/Cebpaflox/flox, E18.5

Martis, et al. 2006

CNB

Dave

Cnb Δ/Δ mice: CCSP-rtTA/(tetO) 7 CMV-Cre/Cnb1flox/flox

Dave, et al. 2006

CTNNB1_ACT

Mucenski

CatnbΔ (ex3) mice: CCSP-rtTA+/tg or tg/tg, (tetO) 7 CMV-Cre+/tg or tg/tg, Catnb+/Δ (ex3)

Mucenski, et al. 2005

CTNNB1_KO

Mucenski

SP-C-rtTA+/tg, (tetO)7-CMV-Cre+/tg or tg/tg, β-cateninflx/flx

Mucenski, et al. 2003

Cyclopamine_

Effect

Shannon

Lung explant culture treated with Cyclopamine for 1-3 days

 

D508

Whitsett

CFTRΔ508 mice: FABP-hCFTR+/-/mCftr-/-/SP-C-Δ508CFTR+/+

Xu, et al. 2006

FGF18_OE

Whitsett

SP-C-rtTA and (teto) 7 CMV-FGF-18

Whitsett, et al. 2002

Fgfr2IIIb

Perl

SP-C-rtTA and (teto) 7 CMV-Fgfr2IIIbflx/flx; E11.5-13.5 lung

Perl, et al. 2003

FoxA2_KO

Whitsett

Foxa2 Δ/Δ mice: SPC-rtTA-/tg/(tetO)7Cre-/tg/Foxa2LoxP/LoxP; E18.5

Wan, et al. 2004

FoxaDKO

Whitsett

Foxa2 Δ/Δ, Foxa1-/- mice: Foxa1-/-/SPC-rtTA-/tg/(tetO)7Cre-/tg/Foxa2LoxP/LoxP; E14.5

Wan, et al. 2005

FoxM1_KO

Whitsett

Foxm1-/- mice; E18.5

Wang, et al.

HIF1KO

Shannon

Hif1 Δ/Δ mice: SPC-rtTA-/tg/(tetO)7Cre-/tg/Hif1flx/flx; PND1

 

LAL

Yan

Lal-/- mice, 4month

Lian, et al. 2004

MIA

Shannon

tetO7-Cre/SPC-rtTA/Mia1, E18.5

Lin, et al. 2008

SHH12.5

Shannon

Shh-/- mice; E12.5

 

SHH13.5

Whitsett

Shh Δ/Δ mice: SP-C-rtTAtg/(tetO) 7 CMV-Cretg/tg/Shhflx/flx; E13.5

Miller, et al. 2004

SHH18.5

Whitsett

Shh Δ/Δ mice: SP-C-rtTAtg/(tetO) 7 CMV-Cretg/tg/Shhflx/flx; E18.5

Miller, et al. 2004

SPA_KO

Levine

alveolar macrophage from Sftpa -/- mice

 

SPC_2M

Glasser

Sftpc-/- mice; 2month

Glasser, et al. 2003

SPC_PND1

Glasser

Sftpc-/- mice, PND1

Glasser, et al. 2008

SPC_typeII

Glasser

Isolated typeII cells from Sftpc -/- mice

Glasser, et al. 2003

SPD_AM

Whitsett

Isolated alveolar macrophage from Sftpd-/- mice

Zhang, et al. 2006

SPD_typeII

Ikegami

isolated typeII cell from Sftpd -/- mice

Korfhagen, et al. 1998

Stat3_tyII

Ikegami

Type II cells from TetO7Cre/SPC-rtTA/Stat3flox/flox, 7 week.

Xu, et al. 2007

SU5402

Shannon

Lung explant culture treated with 0.1% DMSO or SU5402, E12.5

Metzger, et al. 2007

TTF1_Lung

Whitsett

Titf1PM/PM mice:Titf1 phosphorylation mutant, E18.5 lung

DeFelice, et al. 2003

TTF1_Thyroid

Whitsett

Titf1PM/PM mice:Titf1 phosphorylation mutant, E18.5 thyroid

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