Table 7 Selected genes that are less highly expressed in 'Susceptible' than 'Fully Resistant' and 'Control' animals at 72 hours post-inoculation
From: Gene expression profiling in the lungs of pigs with different susceptibilities to Glässer's disease
Genes grouped by function | Genbank human RefSeq ID | S v C fold change | S v FR fold change |
|---|---|---|---|
Extracellular matrix components | |||
Fibronectin type III domain containing 1 (FNDC1) | NM_032532 | -1.78 | -1.86 |
Collagen, type VI, alpha 3 ( COL6A3 ) | NM_057167 | -1.82 | -2.52 |
Fibronectin type III domain containing 3 (FNDC3) | NM_014923 | -1.83 | -2.46 |
Decorin ( DCN ) | NM_133503 | -1.98 | -1.88 |
Extracellular matrix protein 2 ( EMP2 ) | NM_001393 | -2.18 | -2.50 |
EGF-containing fibulin-like extracellular matrix protein 1 (EFEMP1) | NM_018894 | -2.2 | -2.78 |
Secreted protein, acidic, cysteine-rich ( SPARC ) | NM_003118 | -2.2 | -2.78 |
Matrilin 2 ( MATN2 ) | NM_030583 | -2.35 | -2.7 |
Collagen, type I, alpha 1 ( COL1A1 ) | NM_000088 | -2.38 | -3.39 |
Collagen, type III, alpha 1 ( COL3A1 ) | NM_000090 | -2.52 | -3.65 |
Fibronectin 1 ( FN1 ) | NM_212482 | -2.52 | -3.29 |
Dermatopontin ( DPT ) | NM_001937 | -2.73 | -2.75 |
Transforming growth factor, beta-induced ( TGFBI ) | NM_000358 | -3.02 | -3.79 |
Lectin, galactoside-binding, soluble, 3 binding protein ( LGALS3BP ) | NM_005567 | -3.2 | -3.09 |
Asporin (ASPN) | NM_017680 | -3.38 | -3.66 |
Microfibrillar associated protein 5 ( MFAP5 ) | NM_003480 | -5.54 | -4.58 |
ECM growth factor ligand/receptor | |||
Bone morphogenetic protein receptor, type II (BMPR2) | NM_033346 | -1.76 | -2.07 |
Insulin-like growth factor binding protein 5 (IGFBP5) | NM_000599 | -1.76 | -2.17 |
Fibroblast growth factor 17 (FGF17) | NM_003867 | -2.03 | -2.72 |
WNT family, member 5A ( WNT5A ), mRNA | NM_003392 | -2.16 | -2.14 |
P311 protein (P311) | NM_004772 | -6.98 | -9.01 |
Antigen presentation | |||
Proteasome subunit, beta type, 8 ( PSMB8 ) | NM_148919 | -2.06 | -1.83 |
CD1B antigen, b polypeptide ( CD1B ) | NM_001764 | -2.11 | -2.40 |
Major histocompatibility complex, class II, DM alpha ( HLA-DMA ) | NM_006120 | -2.18 | -1.83 |
Major histocompatibility complex, class II, DR alpha ( HLA-DRA ) | NM_019111 | -2.3 | -2.31 |
Cathepsin S (CTSS) | NM_004079 | -2.32 | -1.94 |
Major histocompatibility complex, class II, DM beta ( HLA-DMB ) | NM_002118 | -3.21 | -2.93 |
T cell receptor signaling | |||
T cell receptor alpha locus (TCRA) | NONE | -2.45 | -3.34 |
Dual specificity phosphatase 14 (DUSP14) | NM_007026 | -2.50 | -1.94 |
V-set and immunoglobulin domain containing 4 (VSIG4) | NM_007268 | -2.91 | -2.00 |
GATA binding protein 3 (GATA3) | NM_002051 | -3.00 | -3.22 |
Immunoglobulin genes | |||
Immunoglobulin J polypeptide ( IGJ ) | NM_144646 | -1.90 | -2.73 |
Immunoglobulin kappa chain variable region (IGK) | NONE | -2.36 | -5.05 |
Anti-viral and type I interferon regulated genes | |||
Interferon regulatory factor 9 ( IRF9 ) | NM_006084 | -1.82 | -2.01 |
Hect domain and RLD 5 (HERC5) | NM_016323 | -1.85 | -1.95 |
Interferon regulatory factor 2 binding protein 2 (IRF2BP2) | NM_182972 | -1.90 | -1.95 |
Interferon induced transmembrane protein 3 ( IFITM3 ) | NM_021034 | -2.52 | -2.08 |
Tripartite motif protein TRIM5 isoform alpha ( TRIM5A ) | NM_033034 | -3.02 | -3.00 |
Myxovirus resistance 1 ( MX1 ) | NM_002462 | -3.26 | -2.58 |
Interferon-induced protein 44 (IFI44) | NM_006820 | -3.26 | -2.98 |
Family with sequence similarity 14, member A (FAM14A) | NM_032036 | -3.75 | -2.89 |
Ubiquitin specific protease 18 (USP18) | NM_017414 | -3.84 | -2.65 |
2',5'-oligoadenylate synthetase 1 ( OAS1 ) | NM_002534 | -3.87 | -3.21 |
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1) | NM_001001887 | -4.99 | -3.04 |
DEAD box polypeptide 58 ( DDX58 ) | NM_014314 | -5.30 | -3.70 |
XIAP associated factor-1 (XIAPAF1) | NM_017523 | -6.07 | -5.08 |
ISG15 ubiquitin like modifier ( ISG15 ) | NM_005101 | -6.82 | -3.85 |
Interferon, alpha-inducible protein 6 ( IFI6 ) | NM_002038 | -7.18 | -3.63 |
2'-5'-oligoadenylate synthetase 2 ( OAS2 ) | NM_016817 | -9.55 | -8.96 |