Figure 4

Minimal global inaccessibility of inactive genes in differentiated tissues. Each point represents a gene. The X and Y axes indicate promoter-specific DAM accessibility across the two tissues being compared. The bottom right panel is the comparison between in vitro methylated N2 DNA versus DAM-exposed DNA from muscle tissue. The black line is normalized equivalence; while the blue curves demarcate the level of divergence that is (1) at least two-fold, and (2) statistically significant to P < 0.05