Table 3 Immune-relevant genes/homologues in L. japonicus

Pattern Recognition Genes

T-cell and B-cell Antigen Activation

TLR (1-9,13,14,18,21,23)

44

17

TCR (α,β chain)

6

4

scavenger receptor

19

11

BCL (2,3,6,7,9,10,11) and relevant

44

19

Mannose receptor

49

26

Immunoglobulin and relevant

52

32

MBL

13

9

CD (2-6,8,9,22,40,79,81,97,99,154,166, 226,276)

47

29

NOD (1,2)

7

5

BLNK

5

3

C-type lectin (4,6,7,9-12)

36

26

AICDA

3

2

TOLLIP

1

1

CBLB

7

4

LPS-binding/anchor protein

19

3

DOCK2

4

2

HMG (A,B,2L1,20A)

8

6

DRAM

1

1

LRR-containing proteins

168

74

Glomulin

2

2

NALP (1,3,4,6,9,12,13)

21

8

HDAC (1-8,10,11)

40

23

PGRP

1

1

GALNAC4S-6ST

5

3

BTK

2

2

KLF (1-4,6-9,11-13)

29

15

Fibrinogen

4

4

IGBP1

1

1

Complement System

HLA

1

1

C1 (q,r,s,t),C2-C7,C9,C10

40

32

JAG (1,2)

37

6

Complement factor (B,H,I,properdin, DAF)

22

11

KI13B

17

1

Complement receptor (1,2,5)

13

8

LAG

1

1

MASP

4

3

NCK

7

5

RGC

2

2

Homeobox protein (NKX)

4

3

Inflammatory Cytokines and Receptors

PAWR

3

3

IL (1,3,8,10-12,15,16,27,34) and relevant

34

17

Protein kinase C δ

6

3

ILR (1-3,6,7,10,12,15,17,18,20-22,31) and relevant

48

31

Prolactin receptor

5

2

IFN

3

2

RAG (1,2)

3

2

IFN-induced proteins and relevant

59

27

RGS (1-5,7-9,11,12,14,16,18-20)

47

23

IFN (α,β,ω) receptor

2

1

SFTPD/SP-D

1

1

IFN-related regulator

31

16

TYK2

1

1

CRLF (1,3)

3

2

VAV oncogene family (1-3)

13

6

EBI 2

5

2

WAS proteins

23

11

FND (3,C)

12

4

WWP

2

2

TTN/TITIN

5

2

Antigen Processing and Regulators

CXCL(6,12,14),CXC,CXCR(1-5,7)

20

17

MHC I/II

14

5

CCL(2-4,7,14,16,19,C11b),CCR(2-9,11)

33

26

PSMA (1-7)/B/C/D/E(2-4)

93

63

CX3CR

1

1

Legumain

5

3

XCL(1),XCR(1,1a)

6

3

ITCH

5

2

Chemokine receptor-like

4

2

RFX5

4

1

CFLAR

1

1

TAPBP

3

2

EGF

125

50

ASPP (1,2)

24

4

FAM

15

8

ICAM2

1

1

FGF

23

14

RAC1

3

1

FLT3/CD135

2

2

AGT

4

2

GATA (1-3,5,6)

14

8

CDC (2,5-7,16,20,23,27,42,A)

23

15

GDF

3

3

CDK-inhibitor (1-3)

9

8

GFI-1/-1B

13

3

CTLA4

1

1

GPR44

4

2

Other Genes Related to Immune Cell Response

Inhibin β

1

1

CD (33,34,44,45,48,83,151,302)

10

8

Integrin α/β

89

38

Apolipoprotein A

2

2

LIFR

5

3

HELLS

1

1

Lipoteichoic acid

1

1

IMPDH/IMDH

4

3

MAF

2

2

AP-1

20

15

MIF

3

2

c-FOS

2

2

PCGF (1-3, 5, 6, A)

8

6

EGR

11

5

SCYE1/MCA

3

2

ELK4

1

1

SDF2

2

2

IKKA/CHUK, IKKB

8

2

TGF A/B(1-3)

10

9

JAK (1,2)

11

6

TNF and TNR

54

38

JUN oncogene

11

6

Thrombopoietin

1

1

MALT

5

2

VEGF (A,C,D)

5

4

NFAT

32

12

VEGF receptor (1-3)

17

8

NF κ-B inhibitor proteins

11

4

Adapters, Effectors and Signal Transducers

PPM

33

14

ASB (1-3,5-8,12,13)

26

14

RIPK (1-3,5)

7

5

CRADD

2

1

SLC20A-1/2

6

4

DEDD

4

2

Transcription factor Sp and SPT

21

18

EIF 2-α kinase 2

7

2

TANK-binding kinase

9

5

FADD

1

1

TBX

12

7

Heme oxygenase

4

2

TMED (1-5,7-9,A)

12

10

HTR (5A,5B)

22

4

TRIM (1-3,7-9)

20

8

IRAK (1-4)

7

6

Antimicrobial peptide

2

2

CSF

12

5

Co-chaperone

4

3

Myd88

2

1

Ferritin

1

1

NR2C

6

4

Hepcidin

1

1

PEA15

2

1

HSP (7,13,70-72,74,B)

35

20

PELI (1-3)

21

6

Lysozyme

4

3

PHLA (1-3)

4

3

Macroglobulin

9

6

PPARA

2

2

Microtubule-associated

109

45

REL

1

1

Nitric oxide synthase

4

3

RHOA

3

1

Proteolipid protein

1

1

RIP

2

2

Prohibitin

3

2

SARM1

8

2

Selenoprotein

22

11

SIGIRR

2

2

ABCF

8

7

SMAD (1-7,9)

33

16

CAMP

13

4

SOCS (1-7)

18

8

CARD

5

3

TICAM1

1

1

CEBP

7

5

TIRAP

1

1

DMBT

6

4

TRADD

1

1

PTAFR

1

1

TRAF (2-7)

10

7

Protein S100-A

5

4

TANK

2

2

UCRP/CRP

1

1

UBE

47

25

CYBB

1

1

STAT

21

7

Caspase (1-3,6-9)

18

13

NF κ

15

4

Adenosine receptor A (2a,2b)

11

7

MAPK (1-3,5-9,11-15)

47

29

Apoptotic relevant

13

6

MAP2K4(JUKK1)

2

2

IRG1

4

2

MAP3K (2-9,11,14,15)

35

18

Stress response protein

22

6

MAP3K 7-interacting protein (TAB)

4

4

WSC (1,2,4)

8

3

JNK

5

4

OSGI2

1

1